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Serum neurokinin b levels in newly diagnosed non-dipper hypertensive patients

Session Poster Session III - Friday 08:30 - 12:30

Speaker Aydin Akyuz

Event : ESC Preventive Cardiology (Formerly EuroPrevent) 2015

  • Topic : hypertension
  • Sub-topic : Hypertension
  • Session type : Poster Session

Authors : C Dursun Akkoyun (Tekirdag,TR), A Akyuz (Tekirdag,TR), A Seref (Tekirdag,TR)

Authors:
C Dursun Akkoyun1 , A Akyuz1 , A Seref1 , 1Namik Kemal University Faculty of Medicine - Tekirdag - Turkey ,

Citation:

Purpose:Cardiovascular diseases are more common in patients with non-dipper hypertension (NDHT) compared with those with dipper hypertension (DHT). The purpose of this study is to evaluate the serum neurokinin B levels in DHT and NDHT patients. Methods:The study population consisted of newly diagnosed hypertensive patients who were not under antihypertensive treatment. A total of 77 patients were evaluated with ambulatory blood pressure monitoring and divided into two groups as NDHT (n=42) and DHT (n=35). Plasma neurokinin B levels were measured with ELISA method.

 Results:Serum neurokinin B levels were significantly higher in the NDHT group compared with the DHT group (254(180-888) pg/mL and 207(116-752) pg/mL, respectively; p=0.024). There is a positive correlation between the mean nighttime systolic blood pressure and plasma neurokinin levels (r=0.590; p<0.001). On regression analysis, neurokinin B level was found to be only related to mean nighttime systolic blood pressure (Unstandardized ß= -22.02 ±9.59; p<0.001).

Conclusion:In conclusion, plasma neurokinin B level is higher in patients with NDHT indicating an unfavorable cardiovascular prognosis, and it can be used for the diagnosis and the follow up of the NDHT patients.

Nondipper Hypertension (n=42)

Dipper

Hypertension

(n=35)

P value

Daytime systolic BP, mmHg

145±15

144±13.5

0.321

Daytime diastolic BP, mmHg

91±11

92±10.5

0.550

Nighttime systolic BP, mmHg

141±18

125±11

0.039

Nighttime diastolic BP, mmHg

87±11

80±9.5

0.253

?-Systolic BP

3.6(0-9)

13(10-23)

<0.001

?-Diastolic BP

5.5(1-10)

15(11-28)

<0.001

Heart rate, bpm

85.3±10.7

83.6±11.2

0.496

Daytime heart rate, beats/min

85.3±10.7

83.6±11.2

0.496

Nighttime heart rate, beats/min

68.3±10.3

67.6±11.4

0.694

Neurokinin B, pg/ml

254(180-888)

207(116-752)

0.024

BP: blood pressure, bpm=beats per min. ?:The difference between systolic BP in nighttime and daytime

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