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Seasonal changes of 24-hour arterial stiffness parameters in two regions of the Russian Federation. Results of the cohort study.
V M Gorbunov1
1National Research Center for Preventive Medicine - Moscow - Russian Federation
Purpose: The arterial stiffness variability may be one of the causes of blood pressure seasonal variations in hypertensive patients. The investigation of this problem in Russia deserves particular interest due to great contrasts in climate conditions across different regions. The aim of the study was to assess the dynamics of arterial stiffness (winter vs. summer) in two sites of Russia – Ivanovo ("north") and Saratov ("south"). Methods: We included patients from general population who visited ambulatory clinics for various reasons. The main inclusion criterion was office blood pressure 130/85-139/89 mm Hg or long-term antihypertensive therapy. Ambulatory blood pressure monitoring (ABPM) was performed twice: in winter (December-February) and in summer (June-August). The interval between ABPMs was 6 months±7 days. The selection criteria for ABPM records were: duration =23.5 hours =56 readings per 24 hours. The ABPM waveforms were analyzed by an automatic algorithm calculating the central pulse wave parameters from the peripheral pulse wave. Results: 1423 patients completed the first visit - 641 from Ivanovo (mean age 52±9 years, 244 men), 782 from Saratov (mean age 58±12 years, 449 men). The data of 745 patients with adequate quality of both ABPMs were analyzed. We found no seasonal or intraregional differences for pulse wave velocity (see table). At the same time, the values of both augmentation indices were higher in winter. Conclusions: Our results show the decrease of 24-hour arterial stiffness associated with higher temperature. Further individual analyses of these data, as well as prospective studies in this field, are needed.
PWV - pulse wave velocity, AIx - Augmentation index, ao - aortic, b - brachial, s - summer, w - winter, * - p<0,05 (w vs. s), *** - p<0,001 (w vs. s), ^^^ - p<0,001 (Ivanovo vs. Saratov), ^^^^ - p<0,0001 (Ivanovo vs. Saratov)
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