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Mortality risk due to electrocardiographic disturbances in elderly Russian population

Session Poster Session III - Friday 08:30 - 12:30

Speaker Svetlana Shalnova

Event : ESC Preventive Cardiology (Formerly EuroPrevent) 2015

  • Topic : preventive cardiology
  • Sub-topic : Lipids
  • Session type : Poster Session

Authors : S Shalnova (Moscow,RU), G Muromtseva (Moscow,RU), A Kapustina (Moscow,RU), A Deev (Moscow,RU), Y Balanova (Moscow,RU), E Tuaeva (Moscow,RU), S Evstifeeva (Moscow,RU), D Smirnov (Moscow,RU), M Shkolnikova (Moscow,RU)

Authors:
S Shalnova1 , G Muromtseva1 , A Kapustina1 , A Deev1 , Y Balanova1 , E Tuaeva1 , S Evstifeeva1 , D Smirnov1 , M Shkolnikova2 , 1National Research Center for Preventive Medicine - Moscow - Russian Federation , 2Research Clinical Institute of pediatrics - Moscow - Russian Federation ,

Citation:

Purpose: to assess the prevalence of major and minor electrocardiographic (ECG) abnormalities, as well as their impact into all cause and CVD mortalities among Muscovites aged=55 years. Methods: The data came from a population-based sample of 1876 Muscovites aged=55 years  who participated in SAHR (Survey on Stress, Aging, and Health in Russia).During a median of follow-up period of 5.36 years, 332 deaths  were identified. Standard 12-lead ECG was recorded. ECG abnormalities were divided into six groups (using Minnesota code (MC)): major QQS (MC: 1.1,1.2 without 1.2.8.), major ischemia (MC: 4.1,4.2, 5.1,5.2 without 3.1, 3.3), conduction defects (CD) (MC: 6.1,6.2,7.1), atrial fibrillation (AF) (MC:8.3) and minor QQS abnormalities (MC: 1.2.8, 1.3.-), minor ischemia (4.1- 4.4, 5.1-5.4 with 3.1, 3.3). Cox regression to estimate hazard ratios (HR) for an association between ECG abnormalities and CVD and total mortality was performed. Results: The prevalence of major ECG abnormalities was slightly higher among men than among women (26.7% vs 22.4%, p <0.05), whereas minor ECG – in women (21.9% vs 17.5%, p<0.05). The most difference between sexes was found in groups of major QQS (8.1%  vs 2.8%, p<0.01) in men and women, respectively. The prevalence of all abnormalities increased with age. While using Cox regression model with entire ECG block of ECG variables (age, sex-adjusted) for total mortality the following were significant. AF (HR 1.630, 95%CI: 1.096; 2,423), CD (3.017: 1.743; 5.219), major ischemia (1.610: 1.184; 2.189), minor ischemia (1.338: 1.009; 1.772). Conclusions: The prevalence of major ECG abnormalities was slightly higher among men. AF and CD have much greater effect on mortality in comparison with middle-aged subjects.

Variables

RR

95%CI

p-level

Atrial fibrillation or flatter

1.837

1.142

2.956

0.0122

Conduction defects

3.163

1.589

6.298

0.0010

QQS MAJOR

1.736

1.135

2.653

0.0109

QQS MINOR

0.731

0.358

1.495

0.3906

ISCHEMIA MAJOR

1.707

1.150

2.533

0.0080

ISCEMIA MINOR

1.546

1.082

2.211

0.0168

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