1Kirov State Medical Academy - Kirov - Russian Federation
Purpose. To compare efficacy of the combinations: to achieve the target level of LDL, BP, HbAc%. Methods. 78 patients with moderate arterial hypertension, type 2 diabetes, dyslipidemia were studied. Patients of group A (25) received perindopril/indapamide/simvastatin, of group B (30) - enalapril/indapamide/simvastatin, of group C (23) - enalapril/hydrochlorothiazide/simvastatin.The target levels: BP<130/80 mmperHg, LDL<2 mmol/L. Hypoglycaemic therapy was focused on the achievement of HbAc%.Results. By the 12th week in group A 60% patients achieved the target level of LDL with the dose of 20 mg, 36% - 40 mg, 4% required "atorvastatin" prescription. In group B 23% patients achieved the target level with the dose of 20 mg, 60% - 40 mg, 3% with "atorvastatin" prescription (?<0.05), 14% failed to reach. In group C 57% patients achieved the target level with the dose of 20 mg, 43% -40 mg.By the 12th week all the patients achieved the target level of BP. The minimal antihypertensive effect was reached in group B (?<0.05). Patients with inefficient doubled dose treatment required amlodipine in the dose of 5 mg (2 patients of group B and 1 patient of group A). By the 12th week the level of HbAc% reduced from 8,21±0,38 to 6,94±0,23% in group A, from 8,58±0,38 to 7,19±0,18% in group B, from 8,61±0,31 to 7,24±0,27% in group C (?<0.05). The individual target level of HbAc% was achieved in 72, 53,3 and 69,5% accordingly (p>0.05). Conclusions. Complex influence on CVD risk factors can guarantee more significant result of the individual parameters and more favorable prognosis for the patient.