Introduction: The role of arterial stiffness in the prediction and development of cardiovascular events is widely developed in the literature. However, the effect of the use of mobile technology (mHealth) in the modification of arterial stiffness markers through the modification of lifestyles has not been analyzed.
Objective: To investigate the effect of an intervention consisting of brief advice on life habits added to the management of the EVIDENT II application, on the modification of arterial stiffness markers (Peripheral augmentation index (PAIx75), cardio vascular vascular index (CAVI) and pulse wave velocity (baPWV).
Methods: Randomized clinical trial with two groups in parallel. Each participant made an initial visit and two follow-up visits at 3 and 12 months where the PAIx75 was evaluated by tonometry and the CAVI and the baPWV by oscillometry. Secondary variables included measurements of blood pressure, pulse pressure and heart rate. Both groups (intervention-IG and control-CG) received brief advice on diet and exercise at the first visit. The IG also received instructions for the use of the EVIDENT II application and a mobile was provided with the application for its use during the intervention period (3 months). These instructions included explanations on the specific sections of the application: daily record of food with the selection of food and quantities, daily record of physical activity (type and quantity) and the number of steps, visualization and comparison of all data included in front to reference values.
Results: The sample consisted of 597 people (291 IG, 306 CG), 64% women. The mean age was 52 ± 11 years. There were no baseline differences between groups in any of the variables analyzed. The IG PAIx75 decreased at 3 months (-2.8%, 95%CI -0.5 -5.1 to), maintained at 12 (-2.5%, 95%CI -0.2 -4.8 to). The CAVI and baPWV did not change significantly. The CG increased the numbers of PAIx75 and baPWV at 3 and 12 months, reaching a significant increase at 12 months (0.25, 95%CI 0.11 to 0.39). Comparing groups, there was a decrease in the PAIx75 favorable to the IG at 3 months (-4.9%, 95%CI -7.7 to -2.1) and at 12 months (-3.9%, 95%CI -6.8 to -1.0). There is also a favorable effect on GI in the reduction of CAVI at 3 months without statistical significance. A group effect was observed in the evaluation of the PAIx75 over the 12 months of follow-up (p = 0.003), although only in women was this interaction observed (p = 0.022).
Conclusion: The use of EVIDENT application achieved, by improving lifestyles, a modification of the PAIx75. The impact of mobile technology to modify variables related to cardiovascular diseases was positive.