Methods: Over a year we included 70 consecutive DCM patients (48 ± 12.1 years, EF 24.4 ± 7.4%) with completed baseline, 3- and 12- month follow-up echocardiograms and blood sampling. The grade of DD was estimated for each patient, according to the current ASE/EACVI algorithm. Serum levels of TGF1-ß, CTGF and galectin-3 were measured with ELISA at baseline, 3- and 12-month follow up.
Results: Based on the DD grade patients were divided into 3 groups: 1st grade DD (30 pts), 2nd grade DD (18 pts), and 3rd grade DD (22 pts). At first, kinetics of TGF1-ß rose; however, decreased at 12-month in all three DD groups (Fig.1). CTGF homogeneously decreased over 12-month (Fig. 2). Serum concentrations of galectin-3 remained unchanged during observation (Fig. 3).
Conclusions: Kinetics of TGF and CTGF had the same pattern, i.e. decrease of concentration, regardless of DD grade. Contraction of galectin-3 was homogenous in different DD grades and did not change over follow-up. Key-players of fibrosis have distinct patterns in DCM patients with different DD grades. The clinical meaning of those observations requires further studies.