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12-month kinetics of extracellular matrix fibrosis controlling factors: TGF, CTGF and galectin-3 in dilated cardiomyopathy patients with different grades of diastolic dysfunction.

Session Poster session 4

Speaker Sylwia Wisniowska-Smialek

Event : EuroEcho 2018

  • Topic : imaging
  • Sub-topic : Echocardiography: Systolic and Diastolic Function
  • Session type : Poster Session

Authors : SYLWIA Wisniowska-Smialek (Krakow,PL), E Dziewiecka (Krakow,PL), K Holcman (Krakow,PL), L Khachatryan (Krakow,PL), M Szymonowicz (Krakow,PL), A Karabinowska (Krakow,PL), E Wypasek (Krakow,PL), A Lesniak-Sobelga (Krakow,PL), M Hlawaty (Krakow,PL), M Kostkiewicz (Krakow,PL), P Podolec (Krakow,PL), P Rubis (Krakow,PL)

SYLWIA Wisniowska-Smialek1 , E Dziewiecka1 , K Holcman1 , L Khachatryan1 , M Szymonowicz1 , A Karabinowska1 , E Wypasek1 , A Lesniak-Sobelga2 , M Hlawaty2 , M Kostkiewicz1 , P Podolec1 , P Rubis1 , 1Jagiellonian University Medical College - Krakow - Poland , 2John Paul II Hospital - Krakow - Poland ,

European Heart Journal - Cardiovascular Imaging ( 2019 ) 20 ( Supplement 1 ), i882

Background: Fibrosis of extracellural matrix (ECM) in dilated cardiomyopathy (DCM) is common and it compromises both systolic and diastolic function. Transforming growth factor (TGF1-ß), connective tissue growth factor (CTGF) and galectin-3 are crucial chemokines involved in fibrotic pathways. Little is known on the long-term relations of fibrotic markers and diastolic dysfucntion (DD) in DCM.
Methods: Over a year we included 70 consecutive DCM patients (48 ± 12.1 years, EF 24.4 ± 7.4%) with completed baseline, 3- and 12- month follow-up echocardiograms and blood sampling. The grade of DD was estimated for each patient, according to the current ASE/EACVI algorithm. Serum levels of TGF1-ß, CTGF and galectin-3 were measured with ELISA at baseline, 3- and 12-month follow up.
Results: Based on the DD grade patients were divided into 3 groups: 1st grade DD (30 pts), 2nd grade DD (18 pts), and 3rd grade DD (22 pts). At first, kinetics of TGF1-ß rose; however, decreased at 12-month in all three DD groups (Fig.1). CTGF homogeneously decreased over 12-month (Fig. 2). Serum concentrations of galectin-3 remained unchanged during observation (Fig. 3).
Conclusions: Kinetics of TGF and CTGF had the same pattern, i.e. decrease of concentration, regardless of DD grade. Contraction of galectin-3 was homogenous in different DD grades and did not change over follow-up. Key-players of fibrosis have distinct patterns in DCM patients with different DD grades. The clinical meaning of those observations requires further studies.

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