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Assessment of left ventricular function by two-dimensional speckle tracking analysis in youth with masked hypertension

Session HIT Clinical Case Poster session 3

Speaker Xiuxia Luo

Congress : EuroEcho-Imaging 2018

  • Topic : imaging
  • Sub-topic : Echocardiography: Systolic and Diastolic Function
  • Session type : Poster Session
  • FP Number : P1212

Authors : XX Luo (Shenzhen,CN), YQ Sun (Shenzhen,CN), QR Ge (Shenzhen,CN), J Su (Shenzhen,CN), HK So (Hong Kong,HK), MC Yam (Hong Kong,HK), F Fang (Beijing,CN), YS Zhu (Shenzhen,CN)

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Authors:
XX Luo1 , YQ Sun1 , QR Ge1 , J Su1 , HK So2 , MC Yam3 , F Fang4 , YS Zhu1 , 1Shenzhen Hospital, Southern Medical University, Department of Ultrasonography - Shenzhen - China People's Republic of , 2The University of Hong Kong, Department of Paediatrics and Adolescent Medicine - Hong Kong - Hong Kong SAR People's Republic of China , 3The Chinese University of Hong Kong, Department of Paediatrics, Prince of Wales Hospital - Hong Kong - Hong Kong SAR People's Republic of China , 4Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases - Beijing - China People's Republic of ,

Citation:
European Heart Journal - Cardiovascular Imaging ( 2019 ) 20 ( Supplement 1 ), i793

Background: Masked hypertension (MH) is not rare in youths and it may increase risks of long-term cardiovascular impairment.  However, little attention has been given to the association of this blood pressure phenotype with subclinical cardiac damage in this young group.  The aim of this study was to assess the myocardial deformation and function in the youth with MH using advanced echocardiography.

Methods: Forty young patients with MH (age 18 ± 3 years, 73% males) and 40 age-, sex- and race-matched normotensive volunteers were recruited in our study.  MH was diagnosed if daytime or night-time ambulatory blood pressure (ABP) = 95th percentile for gender and height according to the local reference.  All study subjects underwent 24-hour ABP monitoring and completed two-dimensional echocardiography (2DE) including speckle-tracking analysis (2D-STE).  Quantitative data were determined for left ventricular (LV) ejection fraction (EF), global circumferential strain (CS), longitudinal strain (LS) as well as strain rate.

Results: Ventricular volumes and LVEF were similar between the study groups. However, 2D-STE derived LV global LS and CS were significantly decreased in youth with MH when compared to true normotensives (all P < 0.05, Figure 1).  Moreover, LV systolic and early diastolic longitudinal strain rates in MH subjects were lower than in control group (all P < 0.05, Figure 1), while late diastolic strain rates tended to increase in MH, although without statistically significance.

Conclusion: Youths with MH have evidence of subclinical LV systolic impairment evaluated by speckle-tracking analysis, despite of short disease course.  Thus, MH in youth should be no longer considered an entirely benign entity.



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