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The impact of aging on left atrial size and function: a systematic review and meta-analysis.

Session Poster session 1

Speaker Assistant Professor Flavio D'Ascenzi

Event : EuroEcho 2017

  • Topic : imaging
  • Sub-topic : Echocardiography
  • Session type : Poster Session

Authors : F D'ascenzi (Siena,IT), P Piu (Siena,IT), V Capone (Siena,IT), C Sciaccaluga (Siena,IT), M Solari (Siena,IT), M Cameli (Siena,IT), M Focardi (Siena,IT), S Mondillo (Siena,IT), M Henein (Umea,SE)

Authors:
F D'ascenzi1 , P Piu2 , V Capone1 , C Sciaccaluga1 , M Solari1 , M Cameli1 , M Focardi1 , S Mondillo1 , M Henein3 , 1University of Siena, Department of Medical Biotechnologies, Division of Cardiology - Siena - Italy , 2University of Siena, Department of Medicine, Surgery, and NeuroScience - Siena - Italy , 3Umea University - Umea - Sweden ,

Citation:
European Heart Journal Supplements ( 2017 ) 18 ( Supplement 3 ), iii40

Background: the cardiovascular system is affected by aging, however conflicting results cloud this relationship and data on LA myocardial function and aging are scanty. The aim of this study was to evaluate the impact of aging on LA size and function in healthy subjects.

Methods: We conducted a systematic literature search of MEDLINE database. We included only studies evaluating healthy subjects, with age ranged between 18 and 80 years. Parameters were compared among 4 age groups, <30, 30-45, >45-60, >60 years.

Results: Three hundred twenty-six studies met the inclusion criteria and the final population consisted of 62,821 subjects. LA area and LA volume index did not differ among groups. LA function estimated by speckle-dimensional echocardiography did not change with aging (p=0.25).  A decrease in E/A ratio and an increase in E/e’ ratio with advancing age (p<0.0001 and p=0.001, respectively).

Conclusions: In healthy subjects LA area and LA volume index are not influenced with advancing age. Also LA function assessed by speckle-tracking is not affected by age. Thus, an increase in LA area or in LA volume index and a decrease in LA function should be considered as an expression of pathology rather than part of normal aging.

Mean ± SE

95% CR

p value for age

LA area (cm2)

Age ≤30 years

Age > 30 & Age ≤45

Age > 45 & Age ≤60

Age > 60

14.9 ± 0.9

15.3 ± 0.6

15.8 ± 0.5

16.3 ± 0.9

11.3 - 18.4

12.1 - 18.6

12.6 - 19.1

12.7 - 19.8

0.35

LA volume index (mL/m2)

Age ≤30 years

Age > 30 & Age ≤45

Age > 45 & Age ≤60

Age > 60

22.2 ± 0.6

22.6 ± 0.3

23.1 ± 0.3

23.5 ± 0.6

20.8 - 23.5

21.7 - 23.5

22.1 - 24.0

22.1 - 24.9

0.21

E/A ratio

Age ≤30 years

Age > 30 & Age ≤45

Age > 45 & Age ≤60

Age > 60

1.65 ± 0.03

1.41 ± 0.02

1.18 ± 0.01

0.95 ± 0.02

1.50 - 1.80

1.27 - 1.56

1.04 - 1.32

0.81 - 1.10

< 0.0001

E/e’ ratio

Age ≤30 years

Age > 30 & Age ≤45

Age > 45 & Age ≤60

Age > 60

6.8 ± 0.3

7.3 ± 0.2

7.8 ± 0.2

8.3 ± 0.3

4.8 - 8.9

5.3 - 9.3

5.8 - 9.9

6.2 - 10.4

0.001

PALS (%)

Age ≤30 years

Age > 30 & Age ≤45

Age > 45 & Age ≤60

Age > 60

39.1 ± 2.4

37.8 ± 1.3

36.5 ± 0.8

35.2± 1.7

34.1-44.2

35.1-40.5

34.8-38.3

31.7-38.8

0.25

Left atrial size and function according to age.

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