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Age-related changes in the biomechanics of left ventricular and association with NT-proBNP

Session Poster session 4

Speaker Ekaterina Plokhova

Event : EuroEcho 2015

  • Topic : imaging
  • Sub-topic : Imaging
  • Session type : Poster Session

Authors : EV Plokhova (Moscow,RU), D Akasheva (Moscow,RU), O Tkacheva (Moscow,RU), I Strazhesko (Moscow,RU), E Dudinskaya (Moscow,RU), I Pokshubina (Moscow,RU), V Pykhtina (Moscow,RU), A Kruglikova (Moscow,RU), N Brailova (Moscow,RU), S Boytsov (Moscow,RU)

EV Plokhova1 , D Akasheva1 , O Tkacheva1 , I Strazhesko1 , E Dudinskaya1 , I Pokshubina1 , V Pykhtina1 , A Kruglikova1 , N Brailova1 , S Boytsov1 , 1National Center of Preventive Medicine - Moscow - Russian Federation ,

Eur Heart J Cardiovasc Imaging Abstracts Supplement ( 2015 ) 16 ( Supplement 2 ), ii180

Purpose: The proportion of older people in the population increases. Therefore, the study of cardiovascular aging process becomes more important for therapeutic intervention. This study sought to investigate age-related changes of the biomechanics of left ventricular (LV) by determining different parameters in older people, using speckle tracking echocardiography (STE). N-terminal pro-brain natriuretic peptide (NT-proBNP) is a marker subclinical myocardial dysfunction which increases with advancing age. We examined the relationship NT-proBNP with the parameters of STE.

Methods: 2-D speckle tracking analysis was performed on 151 healthy nonobese volunteers aged 60 to 87 years without history of cardiovascular disease or regular use of medication and significant deviations by 12-lead electrocardiogram. LV myocardial deformations were obtained using off-line analysis program QLAB (Advanced Ultrasound Quantification Software Release 8.1.2 (Philips). Longitudinal LV strain was measured in the 3 apical views; circumferential and radial strains in parasternal short-axis images at the LV basal and apical level. LV peak systolic twist is defined as the value of apical LV systolic rotation – basal LV systolic rotation. Values are mean ± SD. We assessed the intraobserver and interobserver variability for all parameters.The plasma concentration of NT-proBNP was measured with ELISA method. 

Results: In 23 subjects (15%), image quality was insufficient for STE analysis. The subjects were 66.05 ± 7.07 years old, 42% were men. Global longitudinal LV strain was reduced in older people (-16.36 ± 1.26%). Radial strain of LV basal (42.95 ± 5.06%) and LV systolic twist (8.76 ± 1.56°) were increased. Age was significantly related to longitudinal LV strain (β=0.120, p=0.01), radial strain basal (β=0.202, p=0.01) and LV systolic twist (β=0.225, p=0.003). Plasma level of NT-proBNP were associated with age (r=0.56, p=0.002), longitudinal LV strain (r=0.42, p<0.001) and LV systolic twist (r=0.49, p<0.001).

Conclusions: LV longitudinal strain decreases in older people. Radial strain and LV twist increases with aging in order to compensate for the disturbance of the longitudinal deformation or diastolic dysfunction in the elderly. Changes in these parameters are associated with the level of NT-proBNP indicating age-related disorders of myocardial contractility.

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