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Training for a first-time marathon reverses vascular ageing

Session Young Investigator Award session

Speaker Anish Bhuva

Congress : EuroCMR 2019

  • Topic : imaging
  • Sub-topic : Cardiac Magnetic Resonance: Flow Imaging
  • Session type : Abstract Session
  • FP Number : 201

Authors : A Bhuva (London,GB), A D'silva (London,GB), C Torlasco (Milan,IT), S Jones (London,GB), N Nadarajan (London,GB), J Van Zalen (London,GB), R Boubertakh (London,GB), N Chaturvedi (London,GB), G Lloyd (London,GB), S Sharma (London,GB), JC Moon (London,GB), AD Hughes (London,GB), CH Manisty (London,GB)

Authors:
A Bhuva1 , A D'silva2 , C Torlasco3 , S Jones1 , N Nadarajan1 , J Van Zalen4 , R Boubertakh4 , N Chaturvedi1 , G Lloyd4 , S Sharma2 , JC Moon4 , AD Hughes1 , CH Manisty4 , 1University College London, Institute of Cardiovasular Science - London - United Kingdom of Great Britain & Northern Ireland , 2St George's University of London, Cardiology Clinical & Academic Group - London - United Kingdom of Great Britain & Northern Ireland , 3San Luca Hospital of Milan - Milan - Italy , 4Barts Heart Centre - London - United Kingdom of Great Britain & Northern Ireland ,

Citation:
European Heart Journal - Cardiovascular Imaging ( 2019 ) 20 ( Supplement 2 ), ii158

Background: Ageing is strongly associated with aortic stiffening, contributing to increased cardiovascular risk even in healthy individuals. Aortic stiffness is reduced in lifelong athletes, but whether training in novice runners can modify this process remains unclear.

Purpose: To assess the impact of first-time marathon training on age-related increases in aortic stiffness.

Methods: Untrained healthy volunteers were recruited prior to starting training for the London Marathon. Assessment pre-training and two weeks post-marathon included central (aortic) BP (cBP), and phase contrast 1.5T CMR in the ascending (Ao-A) and descending thoracic aorta at two levels (pulmonary artery bifurcation and diaphragm – Ao-P and Ao-D). Aortic distensibility and beta-stiffness (ß, a pressure-independent measure) were measured and correlated with chronological age at baseline to derive biological aortic age before and after training. Data are mean changes (95% confidence intervals).

Results: The cohort comprised 139 first-time marathon completers (age range 21-69 years, 50% male). As expected, increasing age decade was associated with decreasing distensibility by 2.3, 1.9 and 3.1 x10-3mmHg-1 for the Ao-A, Ao-P, and Ao-D respectively (partial r=0.4-0.5), Figure.

Training decreased cSBP and cDBP by 4(2.5-5.3) and 3mmHg(1.6-3.6), Table. With training, descending aortic distensibility increased at both Ao-P and Ao-D levels (by 9%,p=0.009 and 17%,p=0.001), whilst unchanged in the ascending aorta. This translated to a reduction in biological aortic age at Ao-P by 3.9(1.1-7.5) and Ao-D 4.5years(1.8-8.2). ß decreased by 7% at the Ao-D level,p=0.02. Participants with slower marathon running times (Ao-P partial r:-0.20,p<0.05), and older age (Figure) showed a greater increase in descending aortic distensibility with training.

Conclusions: Training for and completing a marathon improves central blood pressure and aortic stiffness even in novice athletes. These changes are the equivalent to a ~4-year reduction in vascular age. These benefits were greatest in older, less fit individuals.

Baseline

Follow-up

p

Central SBP (mmHg)

110

(102,121)

106

(100,114)

<0.001

Central DBP (mmHg)

76

(72,81)

74

(69,78)

<0.001

Distensibility (x10-3.mmHg-1)

Ascending

8.63

(5,11)

8.45

(6,12)

0.14

Proximal Descending

8.52

(6,12)

9.06

(6,13)

0.009

Diaphragmatic Descending

13.63

(11,18)

15.17

(12,21)

0.001

Data are median and interquartile ranges.

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