Purposes: our purpose was: - compare 3D global circonferential, radial and longitudinal strain values calculated with CMR-FT, in a population of HCM patients to healthy subjects; - compare segmental strain in hypertrophic and non hypertrophic segments in HCM patients; - correlate strain values to late gadolinium percentage, type of HCM (obstructive and non obstructive disease); - correlate strain data to clinical variables after an average follow-up of 7 years (major cardiac events, ICD appropriate interventions, occurrence of systolic disfunction and end stage disease).
Methods: 45 patients with HCM and 24 healty subjects, were retrospective selected and 3D global radial, circumferential and longitudinal strain values were calculated with FT-CMR. For segmental strain, 656 myocardial segments of HCM population were analyzed.
Results: our study demonstrates: - HCM patients show a significant difference compare to healthy subjects in global longitudinal (respectively -13,18% and -15,18%; p=0,028), circumferential (-14,23% and 17,27%; p=0,03) and radial (32,18% and 37,69 % p=0,03) strain; - a statistically significant difference were observed in segmental radial (respectively 24,06% and 36,94%; p<0,0001) and longitudinal (-12,35% and -14,58%; p<0,0001) strain in hypertrophic segments compare to non hypertrophic segments and in longitudinal segmental strain of the antero-septal basal segment in obstructive HCM compare to non obstructive HCM (-12,24% and -8,96%; p= 0,013); - a correlation between global longitudinal strain values and the percentage of LGE; - at follow-up increased global longitudinal strain was correlated to a progressive decrease in left ventricle ejection fraction (EF).
Conclusion: CMR-FT in HCM patients can help clinicians to provide a global assessment of the complex mechanism of contractile alterations and to individuate a subgroup of HCM patients at higher risk of developing systolic function alteration at follow-up.