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Myocardial strain assessed by CMR feature tracking in healthy subjects - normal values and influence of different postprocessing softwares

Session Poster session 2

Speaker Carolin Lim

Event : EuroCMR 2019

  • Topic : imaging
  • Sub-topic : Cardiac Magnetic Resonance: Deformation Imaging
  • Session type : Poster Session

Authors : C Lim (Berlin,DE), E Blaszczyk (Berlin,DE), L Riazy (Berlin,DE), S Funk (Berlin,DE), J Schueler (Berlin,DE), L Schmacht (Berlin,DE), S Doganguezel (Berlin,DE), F Von Knobelsdorff-Brenkenhoff (Hausham,DE), J Schulz-Menger (Berlin,DE)

Authors:
C Lim1 , E Blaszczyk1 , L Riazy2 , S Funk1 , J Schueler3 , L Schmacht1 , S Doganguezel1 , F Von Knobelsdorff-Brenkenhoff4 , J Schulz-Menger1 , 1Charité - Campus Berlin Buch (CBB), Working Group on Cardiac MRI - Berlin - Germany , 2Max Delbruck Center for Molecular Medicine, Berlin Ultrahigh Field Facility (B.U.F.F.) - Berlin - Germany , 3Charit?? - Universit??tsmedizin Berlin - Berlin - Germany , 4Hospital Agatharied, Department of Cardiology - Hausham - Germany ,

Citation:
European Heart Journal - Cardiovascular Imaging ( 2019 ) 20 ( Supplement 2 ), ii351

Quantification of myocardial strain is of growing interest in Cardiovascular Magnetic Resonance (CMR). It is a novel postprocessing method providing retrospective analysis of longitudinal, circumferential and radial wall strain based on cine images. It enables detection of subclinical myocardial dysfunction. We aimed to assess age and gender related reference values of myocardial strain in healthy adults and to evaluate the influence of field strength and analysis software.
We included 67 healthy subjects (age 44.3±16.3 y, 31 females) from former studies. 3 age groups: 1. < 35 years (n=25), 2. 35-55 years (n=22) and 3. > 55 years (n=20).
CMR was performed at a 1.5 T in 36 and 3 T Scanner in 31 volunteers. SSFP cine images were acquired in 4CV, 3CV, 2CV and short axis. CVI42 was used for postprocessing. All 67 subjects were additionally analysed with TomTec.
All volunteers had preserved LV function (64.1±4.2 %). No differences were found for global strain between 1.5 T and 3 T (table 1). Global longitudinal strain was equal in females and males and among age groups. Global radialLAX, circumferential and radialSAX strain differed between gender. Circumferential and radialSAX also among age groups (p<0.05). Circumferential and radialSAX strain showed differences between full coverage and 3 slices (p<0.001).
Among different postprocessing softwares global values of longitudinal, radialLAX, circumferential and radialSAX strain differed significantly (p=0.001).
We provided age and gender related reference values for myocardial strain in healthy subjects in 1.5 T and 3 T using CVI42. Among different vendors of postprocessing applications differing strain values must be considered when evaluating studies.

Global longitudinal strain [%] p value Global radialLAX strain [%] p value Global circumferential strain [%] p value Global radialSAX strain [%] p value
1.5 T -17.0±2.1 0.845 29.1±5.8 0.792 -19.6±2.3 0.263 36.0±7.5 0.128
3 T -17.0±1.7 29.1±4.6 -18.8±2.2 33.0±6.2
Females -17.4±2.0 0.098 30.7±5.7 0.033 -20.0±2.2 0.010 36.9±7.2 0.014
Males -16.6±1.8 27.8±4.5 -18.6±2.1 32.7±6.4
Age group 1 -16.6±1.8 0.312 28.0±4.8 0.294 -18.3±2.2 0.041 31.8±6.0 0.042
Age group 2 -17.3±1.8 29.6±5.1 -19.5±2.3 35.4±7.6
Age group 3 -17.1±2.2 30.0±6.0 -20.1±2.0 37.2±6.8
Full coverage -17.6±1.8 <0.001 29.1±4.8 <0.001
3 SAX -19.2±2.3 34.6±7.1
CVI42 -17.0±1.9 <0.001 29.1±5.3 <0.001 -19.2±2.3 0.001 34.6±7.1 <0.001
TomTec -20.5±2.7 70.1±21.0* -20.7±2.6 63.7±16.0*
*p<0.05 between 1.5 T and 3 T within one software.

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