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Dark-Blood T1 SAPPHIRE mapping gives cleaner myocardial signal at both 1.5T and 3T

Session Poster session 2

Speaker Joao Andre Bicho Augusto

Event : EuroCMR 2019

  • Topic : imaging
  • Sub-topic : Cardiac Magnetic Resonance: Physics and Technology
  • Session type : Poster Session

Authors : JA Bicho Augusto (London,GB), M Alfarih (London,GB), K Knott (London,GB), D Radenkovic (London,GB), N Chaturvedi (London,GB), AD Hughes (London,GB), R Boubertakh (London,GB), JC Moon (London,GB), S Weingartner (Minneapolis,US), G Captur (London,GB)

JA Bicho Augusto1 , M Alfarih1 , K Knott1 , D Radenkovic1 , N Chaturvedi1 , AD Hughes1 , R Boubertakh2 , JC Moon2 , S Weingartner3 , G Captur1 , 1University College London - London - United Kingdom of Great Britain & Northern Ireland , 2Barts Health NHS Trust - London - United Kingdom of Great Britain & Northern Ireland , 3University of Minnesota - Minneapolis - United States of America ,

Cardiac Magnetic Resonance: Physics and Technology

European Heart Journal - Cardiovascular Imaging ( 2019 ) 20 ( Supplement 2 ), ii325

Background: Partial-voluming effects at the myocardial-blood interface may falsely increase myocardial T1 mapping times.

Purpose: We hypothesize that dark-blood (DB) native myocardial T1 times by SAPPHIRE (modified Saturation Pulse Prepared Heart-rate independent Inversion Recovery) have significantly less myocardial signal contamination from blood in comparison to conventional bright-blood T1 mapping at 1.5T and 3T.

Methods: Same-day CMR was prospectively performed on 10 healthy volunteers (36.2±10.0 years, 20% males) at 1.5T and 3T (Aera/Prisma, Siemens) using both conventional and DB SAPPHIRE. Mean T1 times per slice (basal, mid and apical short-axis) and global values were measured.  Endocardial and epicardial borders were manually drawn with a 10% offset. Normal ranges were defined as mean ± 2 standard deviations. Mean values are presented.

Results: Normal ranges at 1.5T were 1228-1383ms for conventional SAPPHIRE and 1180-1302ms for DB SAPPHIRE. T1 times were significantly lower by DB vs conventional SAPPHIRE in global myocardial assessment. (1241 vs 1305ms, p=0.005). No significant in the basal (1229 vs 1281ms, p=0.075) or mid slices (1245 vs 1270ms, p=0.263), but apical slices had lower T1 values using DB SAPPHIRE (1246 vs 1348ms, p=0.043).

Normal ranges at 3T were 1557-1731ms for conventional SAPPHIRE and 1524-1666ms for DB SAPPHIRE. Global myocardial T1 times were significantly lower by DB vs conventional SAPPHIRE (1595 vs 1644ms, p=0.015) but not in slice-specific reads (basal: 1598 vs 1639ms, p=0.138; mid: 1598 vs 1598ms, p=0.612; apical: 1608 vs 1666ms, p=0.109). The myocardial signal intensity range in DB SAPPHIRE was smaller vs conventional SAPPHIRE (Figure).

Conclusion: Black-blood SAPPHIRE T1 mapping significantly reduces myocardial signal contamination from blood at both 1.5 and 3T and may have value in the deep-phenotyping of thin-walled hearts.

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