Materials and methods: 103 patients from the center of hereditary cardiac diseases were prospectively included. 53 patients with LGE underwent different semi-automated quantification methods for LGE evaluation: nSD-Standard Deviation (from 2 to 6SD) and FWHM (full width at half maximum) with a direct comparison with reference method using manual tracing. Inter- and intra- Observer reproductibility have been assessed.
Results: FWHM and 5SD methods were the closest to the manual technique for LGE quantification (respectively 10,8±7,5% and 9,3±7,4% versus 10,3±8,1% for manual tracing, p<0,01). 2SD, 3SD and 4SD overestimated the results, whereas 6SD technique underestimated the results compared to the manual method. Intra and inter- reproducibility were fine with a better results using FWHM method.
Conclusion: 5SD and especially FWHM methods were the most reliable and reproducible semi-automatic techniques for LGE quantification in patients with HCM using CMR.