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Three-year major clinical outcomes of phosphorylcholine polymer- versus BioLinx polymer-zotarolimus-eluting stents: A propensity score matching study

Session Poster Session 6

Speaker Yong Hoon Kim

Event : ESC Congress 2018

  • Topic : interventional cardiology and cardiovascular surgery
  • Sub-topic : Coronary Intervention: Stents
  • Session type : Poster Session

Authors : YH Kim (Chuncheon City,KR), A-Y Her (Chuncheon City,KR), S-W Rha (Seoul,KP), BG Choi (Seoul,KP), A Mashaly (Seoul,KP), Y Park (Seoul,KP), WY Jang (Seoul,KP), W Kim (Seoul,KP), JY Choi (Seoul,KP), EJ Park (Seoul,KP), JO Na (Seoul,KP), CU Choi (Seoul,KP), EJ Kim (Seoul,KP), CG Park (Seoul,KP), HS Seo (Seoul,KP)

Y.H. Kim1 , A.-Y. Her1 , S.-W. Rha2 , B.G. Choi2 , A. Mashaly2 , Y. Park2 , W.Y. Jang2 , W. Kim2 , J.Y. Choi2 , E.J. Park2 , J.O. Na2 , C.U. Choi2 , E.J. Kim2 , C.G. Park2 , H.S. Seo2 , 1Kangwon National University Hospital - Chuncheon City - Korea Republic of , 2Korea University Guro Hospital - Seoul - Korea Republic of ,

European Heart Journal ( 2018 ) 39 ( Supplement ), 1151

Purpose: Because there are limited long-term outcome data comparing BioLinx polymer (B)-zotarolimus-eluting stents (ZESs) with phosphorylcholine polymer (P)-ZESs. We try to compare the efficacy and safety of B-ZESs with P-ZESs in patients underwent percutaneous coronary intervention (PCI) during 3-year follow-up period.

Methods: Finally, 1254 patients who underwent PCI with P-ZESs (Endeavor® [ZES-E] or Endeavor sprint® [ZES-S], n=356) or B-ZESs (Endeavor resolute® [ZES-R] or Resolute Integrity® [ZES-I], n=889) were enrolled. The primary endpoint was major adverse cardiac events (MACE); the composite of total death, non-fatal myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR), non-target vessel revascularization (Non-TVR) and the secondary endpoint was stent thrombosis (ST) up to 3 years.

Results: After PSM, two propensity-matched (PSM) groups (275 pairs, n=550, C-statistic = 0.730) were generated. During the 3-year follow-up period, the cumulative incidence of total death, cardiac death, MI, total revascularization, TLR, TVR, non-TVR, MACE (HR, 1.525; 95% CI, 0.920–2.526; p=0.101) and ST (HR, 1.248; 95% CI, 0.335–4.4649; p=0.101) were similar between P-ZESs and B-ZESs after PSM. However, TLR rate was significantly higher in ZES-S than ZES-I (11.3% vs. 3.8%, log rank p=0.029) and TVR rate was higher in ZES-S than ZES-R (14.1% vs. 4.8%, log rank p=0.025) (Figure).

Conclusions: B-ZESs showed comparable safety and efficacy with P-ZESs. However, TLR rate was higher in ZES-S compared to ZES-I, TVR rates were higher in ZES-S compared with ZES-R during 3-year follow-up periods.

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