In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.

This content is currently on FREE ACCESS, enjoy another 18 days of free consultation

In these unprecedented times, the ESC is doing everything it can to support its community: FREE access to all ESC 365 content until 31 July: explore more than 125,000 educational resources.

From 1 August onwards, support our mission by becoming a member.

Analysis of myocardial fibrosis using cardiac magnetic resonance T1 imaging and late gadolinium enhancement: Association with ventricular tachycardia in hypertrophic cardiomyopathy

Session Poster Session 4

Speaker Akiko Sakai

Event : ESC Congress 2018

  • Topic : imaging
  • Sub-topic : T1 and T2 Mapping, T2*
  • Session type : Poster Session

Authors : T Abe (Tokyo,JP), A Sakai (Tokyo,JP), E Watanabe (Tokyo,JP), M Nagao (Tokyo,JP), S Sakai (Tokyo,JP), N Hagiwara (Tokyo,JP)

T. Abe1 , A. Sakai1 , E. Watanabe1 , M. Nagao2 , S. Sakai2 , N. Hagiwara1 , 1Tokyo Women's Medical University, cardiology - Tokyo - Japan , 2Tokyo Women's Medical University, Department of Diagnostic Imaging & Nuclear Medicine - Tokyo - Japan ,

European Heart Journal ( 2018 ) 39 ( Supplement ), 775

Introduction: Myocardial fibrosis is a risk factor for ventricular tachycardia (VT) and the worsening of heart failure in patients with hypertrophic cardiomyopathy (HCM). The present study investigates whether myocardial fibrosis using cardiac magnetic resonance T1 imaging and late gadolinium enhancement (LGE) could be a surrogate marker for VT in patients with HCM.

Methods: A total of 57 patients with HCM (mean age 58±15 years, 84% men)underwent LGE and saturation recovery T1 measurements with 3 Tesla scanner to quantify myocardial fibrosis. The extracellular volume (Septal-ECV, %) for mid-left ventricular septum was calculated by T1 values pre- and post-LGE. LGE volume (cm3) for the whole left ventricle was measured using the cutoff of more than 6 standard deviation of normal myocardial intensity. Comparison of septal-ECV and LGE volume between patients with and without VT was analyzed.

Results: VT was observed in 22 (38%) of 57 patients. Septal-ECV and LGE volume was significantly greater for patients with VT than those without (33±17% vs. 25±11%, 22±11cm3 vs. 14±9cm3, p<0.05). The optimal cutoffs of septal-ECV and LGE volume can predict patient with VT with an area under the curve of 0.63 and 0.7.

Conclusion: Septal-LGE and LGE volume can be used as a surrogate marker for VT in HCM. LGE volume is more precise in the prediction of VT than septal-ECV.

Based on your interests

Members get more

Join now
  • 1ESC Professional Members – access all resources from general ESC events 
  • 2ESC Association Members (Ivory, Silver, Gold) – access your Association’s resources
  • 3Under 40 or in training - with a Combined Membership, access all resources
Join now

Our sponsors

ESC 365 is supported by Bayer, Boehringer Ingelheim and Lilly Alliance, Bristol-Myers Squibb and Pfizer Alliance, Novartis Pharma AG and Vifor Pharma in the form of educational grants. The sponsors were not involved in the development of this platform and had no influence on its content.

logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are