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The analgesic effect of oxygen in suspected acute myocardial infarction: a substudy of the DETO2X-AMI trial

Session Poster Session 3

Speaker David Sparv

Event : ESC Congress 2018

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Coronary Artery Disease – Treatment
  • Session type : Poster Session

Authors : JL Sparv (Lund,SE), RH Hofmann (Stockholm,SE), SJ James (Uppsala,SE), JL Lauermann (Jonkoping,SE), EO Omerovic (Goteborg,SE), EH Haugen (Sundsvall,SE), RJ Linder (Stockholm,SE), NW Witt (Stockholm,SE), DE Erlinge (Lund,SE)

Authors:
J.L. Sparv1 , R.H. Hofmann2 , S.J. James3 , J.L. Lauermann4 , E.O. Omerovic5 , E.H. Haugen6 , R.J. Linder7 , N.W. Witt2 , D.E. Erlinge1 , 1Lund University Hospital, Department of Cardiology - Lund - Sweden , 2Karolinska Institute - Stockholm - Sweden , 3Uppsala Clinical Research Center - Uppsala - Sweden , 4Ryhov County Hospital - Jonkoping - Sweden , 5Sahlgrenska Academy - University of Gothenburg - Goteborg - Sweden , 6Sundsvall Hospital - Sundsvall - Sweden , 7Danderyd University Hospital - Stockholm - Sweden ,

On behalf: the DETO2X-Swedeheart Investigators

Citation:
European Heart Journal ( 2018 ) 39 ( Supplement ), 546

Background and purpose: Supplemental oxygen in normoxemic patients with acute myocardial infarction (AMI) does not provide clinical benefit. However, oxygen may relieve ischemic pain.

Methods: In this substudy of the DETO2X-AMI trial, we aimed to assess the analgesic effect of oxygen in AMI patients treated with percutaneous coronary intervention (PCI) and to study the effect of oxygen supplementation on the use of opiates and sedatives during PCI. Patients were allocated to oxygen or ambient air according to the main study protocol. After PCI, peak level of pain during PCI was measured by the Visual-Analogue-Scale. The total amount of opiates and sedatives was reported.

Results: 622 patients were enrolled, 330 in the oxygen group and 292 in the ambient air group. There was no significant difference in peak level of pain (Oxygen: 4.0 [1.0–6.0] vs Air: 3.0 [0.6–6.0], p=0.37), use of opiates (mg) (Oxygen: 0.0 [0.0–3.0] vs Air: 0.0 [0.0–3.0], p=0.31) or use of sedatives between the groups (Oxygen: 2.5 [0.0–2.5] vs Air: 2.5 [0.0–2.5], p=0.74) (median, [interquartile range]).

Conclusions: In the present study, we did not find any analgesic effect of supplemental oxygen as compared to ambient air, and no differences in the use of sedatives and opiates during PCI. Our results indicate that supplemental oxygen does not relieve pain in normoxemic patients with suspected AMI undergoing treatment with PCI.

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