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Dysregulation of insulin levels in Chagas heart disease is associated with altered adipocytokine levels

Session Poster Session 2

Speaker Assistant Professor Fabio Fernandes

Congress : ESC Congress

  • Topic : valvular, myocardial, pericardial, pulmonary, congenital heart disease
  • Sub-topic : Chagas Disease
  • Session type : Poster Session
  • FP Number : P1602

Authors : A Dabarian (Sao Paulo,BR), C Mady (Sao Paulo,BR), JMB Ferreira (Sao Paulo,BR), B Ianni (Sao Paulo,BR), VT Hotta (Sao Paulo,BR), FJA Ramires (Sao Paulo,BR), HF Lopes (Sao Paulo,BR), F Fernandes (Sao Paulo,BR)

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Authors:
A. Dabarian1 , C. Mady1 , J.M.B. Ferreira1 , B. Ianni1 , V.T. Hotta1 , F.J.A. Ramires1 , H.F. Lopes1 , F. Fernandes1 , 1Heart Institute (InCor) - University of Sao Paulo Faculty of Medicine Clinics Hospital - Sao Paulo - Brazil ,

Citation:
European Heart Journal ( 2018 ) 39 ( Supplement ), 312

Background: Metabolic, inflammatory, and autonomic nervous system dysfunctions are present in patients with heart failure (HF). However, whether these changes are due to left ventricular dysfunction or heart failure is unknown.

Methods: We evaluated metabolism and inflammatory activity in patients with idiopathic dilated cardiomyopathy (IDC) and chagasic cardiomyopathy (CHG) and their correlation with the autonomic nervous system (ANS). Forty-six patients were divided into 3 groups: IDC, CHG, and control (CG). All patients underwent anthropometric measurements. Levels of adiponectin, leptin, insulin, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were assayed in serum samples using ELISA. ANS was assessed by heart rate variability in time and frequency domains on a 24-hour Holter monitor. High-frequency (HFr) component values were used to estimate parasympathetic activity, and low-frequency (LFr) component values were used for sympathetic activity. Analyzes were made of the correlations of each of the metabolic parameters (insulin, leptin, and adiponectin) with the inflammatory cytokines (interleukin-6 and TNF-alpha) and with ANS assessment measurements.

Results: No differences were noted between groups regarding blood glucose levels, total cholesterol, leptin, and adiponectin. Insulin levels were lower in CHG 5.4±3.3 μU/mL compared with that in CG 8.0±4.9 μU/mL and IDC 9.9±5.0 μU/mL (p=0.007). Levels of interleukin-6 and tumor necrosis factor-alpha were also higher in CHG compared with that in the other groups. Insulin was positively associated with leptin (r=0.579; p=0.024), LFr/HFr ratio (r=0.562; p=0.029), and with the LFr component (r=0.562; p=0.029) in CHG. Insulin levels were negatively associated with adiponectin (r = -0.603; p=0.017). The addition of an adiponectin unit reduced average insulin by 0.332 ug/mL. A decrease was noted in insulin levels in CHG compared with that in IDC and CG. Insulin levels were associated with ANS parameters and adiponectin.

This content is available only to ACCA members, members with an all access option or Fellows of the ESC

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