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Higher carotid artery temperature is associated with increased cardiovascular event rate. Results from two-year follow-up of a multicenter study

Session Poster Session 2

Speaker Konstantinos Toutouzas

Event : ESC Congress 2018

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Coronary Artery Disease – Epidemiology, Prognosis, Outcome
  • Session type : Poster Session

Authors : G Benetos (Athens,GR), K Toutouzas (Athens,GR), G Oikonomou (Athens,GR), I Koutagiar (Athens,GR), M Karmpalioti (Athens,GR), N Barampoutis (Patras,GR), P Davlouros (Patras,GR), E Siores (Bolton,GB), P Sfikakis (Athens,GR), D Tousoulis (Athens,GR)

Authors:
G. Benetos1 , K. Toutouzas1 , G. Oikonomou1 , I. Koutagiar1 , M. Karmpalioti1 , N. Barampoutis2 , P. Davlouros2 , E. Siores3 , P. Sfikakis4 , D. Tousoulis1 , 1Athens School of Medicine, 1st Department of Cardiology, Hippocration General Hospital of Athens - Athens - Greece , 2University Hospital of Patras, Department of Cardiology - Patras - Greece , 3University of Bolton, Center of Material Research and Innovations - Bolton - United Kingdom , 4Laiko University General Hospital, 1st Department of Propedeutic and Internal Medicine - Athens - Greece ,

Citation:
European Heart Journal ( 2018 ) 39 ( Supplement ), 345

Introduction: The association of inflammation with prognosis in atherosclerosis is well recognized. Microwave radiometry (MWR) allows the noninvasive assessment of the internal temperature of carotid arteries, reflecting inflammation.

Purpose: To investigate whether patients with documented coronary artery disease (CAD) and increased carotid inflammation suffer more common cardiovascular events.

Methods: Consecutive patients with significant CAD as documented by coronary angiography from three tertiary centers were included in the study. Maximum carotid plaque thickness was assessed in all carotidsby ultrasound. ΔT by MWR was assigned as the temperature difference (maximalminus minimum) along the carotid artery. ΔT ≥0.90°C was assigned as high ΔT. Major cardiovascular event (MACE) was defined as death, stroke, myocardial infarction or revascularization. All patients were followed-up clinically for two years.

Results: In total300 patients were included in the study. Two hundred sixty (86.7%) were men. High ΔT temperatures bilaterally were measured in 47 patients (15.7%). During the two-year follow-up period, 36 MACE were recorded (rate 12%). Of them 14 occurred in patients with bilateral high ΔT versus 22 in the remaining 253 patients (n=14, 29.8% versus n=22, 8.7%, p<0.001). By multivariate proportional hazard model, ΔT was independently associated with MACE, when adjusted for sex, age contemporary risk factors, the extent of angiographic severe CAD and maximum carotid plaque thickness (HR=3.62, 95% CI 1.76–7.43, p<0.001). In Kaplan-Meier plots patients with bilateral high ΔT showed higher event rate (log-rank p<0.001,figure, panel A), including death (log rank p=0.05, figure panel B).

Conclusions: Bilateral increased carotid temperatures predict high two-year cardiovascular event rates.

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