In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.


The free consultation period for this content is over.

It is now only available year-round to ESC Professional Members, Fellows of the ESC, and Young combined Members

Right ventricular and pulmonary vascular function indices for risk stratification of patients with pulmonary regurgitation

Session Poster Session 2

Speaker Alexander Egbe

Congress : ESC Congress 2018

  • Topic : valvular, myocardial, pericardial, pulmonary, congenital heart disease
  • Sub-topic : Congenital Heart Disease - Diagnostic Methods
  • Session type : Poster Session
  • FP Number : P1614

Authors : A Egbe (Rochester,US), MA Al-Otaibi (Rochester,US), N Sharma (Rochester,US), M El-Harasis (Rochester,US)

15 views

Authors:
A. Egbe1 , M.A. Al-Otaibi1 , N. Sharma1 , M. El-Harasis1 , 1Mayo Clinic - Rochester - United States of America ,

Citation:
European Heart Journal ( 2018 ) 39 ( Supplement ), 315

Background: We hypothesized that echocardiographic indices of right ventricular to pulmonary artery (RV-PA) coupling were comparable to cardiac magnetic resonance imaging (CMRI) derived RV volumetric indices in predicting disease severity in pulmonary regurgitation.

Methods: Patients with ≥ moderate pulmonary regurgitation in our clinic, 2003–2015, were identified, and those with and without CMRI were enrolled into the study cohort and validation cohort respectively. Endpoint was to determine the association between echocardiographic indices of RV-PA coupling (tricuspid annular plane systolic excursion/right ventricular systolic pressure [TAPSE/RVSP] and fractional area change [FAC]/RVSP ratio) and markers of disease severity, and compared this association to that of CMRI-derived RV volumetric indices and markers of disease severity (peak oxygen consumption [VO2], NT-proBNP and history of atrial and/or ventricular arrhythmia)

Results: Of the 256 patients in the study cohort (age 33±6 years), 187 (73%) had tetralogy of Fallot while 69 (25%) had valvular pulmonic stenosis. TAPSE/RVSP (r=0.73, p<0.001) and FAC/RVSP (r=0.78, p<0.001) correlated with peak VO2. Among the CMRI-derived RV volumetric indices analyzed, only right ventricular end-systolic volume index correlated with peak VO2 (r=-0.54, p<001) and NT-proBNP (r=0.51, p<0.001). These RV-PA coupling indices were tested in a validation cohort of 218 patients (age 37±9 years). Similar to the observation in the study cohort, TAPSE/RVSP (r=0.59, p<0.001) and FAC/RVSP (r=0.70, p<0.001) correlated with peak VO2.

Conclusion: Echocardiographic indices of RV-PA coupling were comparable to RVESVI in predicting exercise capacity in patients with pulmonary regurgitation, and may be important in the assessment of patients with contraindications to CMRI.

The free consultation period for this content is over.

It is now only available year-round to ESC Professional Members, Fellows of the ESC, and Young combined Members



Based on your interests

Three reasons why you should become a member

Become a member now
  • 1Access your congress resources all year-round on the New ESC 365
  • 2Get a discount on your next congress registration
  • 3Continue your professional development with free access to educational tools
Become a member now

Our sponsors

ESC 365 is supported by Bayer, Boehringer Ingelheim, Bristol-Myers Squibb and Pfizer Alliance, and Novartis Pharma AG. The sponsors were not involved in the development of this platform and had no influence on its content.

logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are