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Association of alcohol consumption with aortic root dilatation: Corinthia study

Session Poster Session 1

Speaker Evangelos Oikonomou

Event : ESC Congress 2018

  • Topic : diseases of the aorta, peripheral vascular disease, stroke
  • Sub-topic : Diseases of the Aorta Lifestyle Modification
  • Session type : Poster Session

Authors : E Oikonomou (Athens,GR), G Lazaros (Athens,GR), E Christoforatou (Athens,GR), C Chasikidis (Athens,GR), E Stofa (Athens,GR), GA Papamikroulis (Athens,GR), G Vogiatzi (Athens,GR), S Tsalamandris (Athens,GR), E Bourouki (Athens,GR), E Zacharia (Athens,GR), M Anastasiou (Athens,GR), T Mavrantzas (Athens,GR), M Papakonstantinou (Athens,GR), P Anastasopoulou (Athens,GR), D Tousoulis (Athens,GR)

Authors:
E. Oikonomou1 , G. Lazaros1 , E. Christoforatou1 , C. Chasikidis1 , E. Stofa1 , G.A. Papamikroulis1 , G. Vogiatzi1 , S. Tsalamandris1 , E. Bourouki1 , E. Zacharia1 , M. Anastasiou1 , T. Mavrantzas1 , M. Papakonstantinou1 , P. Anastasopoulou1 , D. Tousoulis1 , 1Hippokration Hospital, University of Athens, 1st Department of Cardiology - Athens - Greece ,

Citation:
European Heart Journal ( 2018 ) 39 ( Supplement ), 113

Introduction: The harmful effects of excessive alcohol consumption on the cardiovascular system as well as on general health are already known. However, data on the incidence of alcohol in aortic diseases are isolated.

Purpose: The aim of this study was to investigate the possible association of excessive alcohol consumption with aortic root dilation.

Methods: We examine 1043 participants (467 men, aged between 30 and 98) of the Corinthia study. Among other tests, echocardiography was performed and subjects were asked to complete questionnaires. Several demographic and clinical characteristics were recorded. Alcohol consumption was assessed on the basis of the questionnaire replies. Subjects with daily consumption of alcohol were categorized as habitual alcohol consumers (HAC) and those consuming alcohol occasionally were categorized as social drinkers (SD).

Results: Of the total studied population, 448 individuals (43%) were found to be HAC. Between HAC and SD there was no difference in age (65±12y vs. 64±11y, p=0.12) and the indidence of hypertension, whereas there was an increased prevalence of male gender in the HAC groups compared to SD (60% vs. 40%, p<0.001). Also, HAC had an increased aortic root diameter (AoRD) (33.61±4.13mm vs. 31.83±4.41mm, p<0.001) and an elevated AoRD index (17.43±2.23mm/m2 vs. 16.84±2.32mm/m2, p<0.001). Interestingly, individuals with an aortic root aneurysm (AoRD>40mm) were more often HAC (61% versus 39%, p=0.01). In addition, depending on the daily alcohol consumption, a gradual increase in the dimensions of AoRD (0–1glass: 31.99±3.65mm vs. 1–2 glasses: 33.65±3.73mm vs. >3 glasses: 34.58±4.44mm, p<0.001) and in AoRD index (0–1 glass: 16.95±2.18mm/m2 vs. 1–2 glasses: 17.45±2.07mm/m2 vs. >3 glasses: 17.39±2.39mm/m2, p<0.04) was observed (Figure 1, panel A, B). Even after adjustment for many confounders such as age, gender, smoking, hypertension and body surface area, the amount of alcohol consumption appeared to be significantly associated with aortic root dilation (B coefficient = 0.55, 95% CI: 0.09–1.01, p=0.02) (Figure 1, panel C).

Conclusion: Systemic alcohol consumption is associated with increased aortic root diameter. These findings shed light on the pathophysiologic mechanisms underlying dilatation of ascending aorta and may be used to highlight novel risk factors.

Figure 1

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