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Polymorphisms in Fc receptor genes are related to antibody-mediated rejection after heart transplantation.

Session Advanced heart failure: new aspects

Speaker Maria Generosa Crespo-Leiro

Event : ESC Congress 2018

  • Topic : heart failure
  • Sub-topic : Heart Transplantation
  • Session type : Moderated Posters

Authors : G M Marron Linares (A Coruña,ES), L Nunez Fernandez (A Coruña,ES), E Alvarez-Lopez (A Coruña,ES), MG Crespo-Leiro (A Coruna,ES), E Barge-Caballero (A Coruna,ES), J Muniz-Garcia (A Coruna,ES), CD Tan (Cleveland,US), ER Rodriguez (Cleveland,US), JM Vazquez-Rodriguez (A Coruna,ES), M Hermida-Prieto (A Coruña,ES)

Authors:
G.M. Marron Linares1 , L. Nunez Fernandez1 , E. Alvarez-Lopez1 , M.G. Crespo-Leiro2 , E. Barge-Caballero2 , J. Muniz-Garcia2 , C.D. Tan3 , E.R. Rodriguez3 , J.M. Vazquez-Rodriguez2 , M. Hermida-Prieto1 , 1Instituto de Investigaciόn Biomédica de A Coruña (INIBIC)-CHUAC-UDC, Grupo de investigaciόn en cardilogía - A Coruña - Spain , 2Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas-INIBIC-UDC, Department of Cardiology - A Coruna - Spain , 3Cleveland Clinic, Department of Anatomic Pathology, Heart and Vascular Institute - Cleveland - United States of America ,

Citation:
European Heart Journal ( 2018 ) 39 ( Supplement ), 855

Background: Heart transplantation (HT) is a well-established life-saving treatment for patients presenting with end-stage cardiac failure. However, antibody-mediated rejection (AMR) represents one of the main problems after HT because of its diagnostic complexity and poor evidences supporting treatments. Fc receptors for IgG (FCγR) are involved in the activation of innate effector cells, antigen presentation, immune-complex-mediated maturation of dendritic cells, and regulation of B-cell activation that produce antibodies. Thus, Fc receptors could influence the development of AMR.

Methods: Genetic variants in 5 genes encoded to low affinity immunoglobulins gamma Fc region receptors (FCGR1A,FCGR2A,FCGR2B,FCGR3A,and FCGR3B) were analyzed by next generation sequencing in 46 HT patients, 23 with and 23 without AMR and 28 donors, 14 donors from patients with and 14 donors from patients without AMR.

Results: We have identified 3 SNPs [p.Gln63Trp and p.Pro215 (p=) in FCGR2A gene, and p.Leu102His/Arg in FCGR3A gene], which correlates with the development of AMR. Moreover, it has been showed that 2 SNPs in FCGR2A conforms an haplotype TGG-FCGR2A, associated with development of AMR in HT patients.

Conclusions: Polymorphisms in the genes related to FCγR could have an important role in the development of AMR.

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