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Patients with peripheral arterial disease show an ameliorated proinflammatory status over 12 months non-supervised exercise training parallel to an increased walking distance

Session Poster Session 7

Speaker Joern Fredrik Dopheide

Event : ESC Congress 2013

  • Topic : preventive cardiology
  • Sub-topic : Exercise Testing
  • Session type : Poster Session

Authors : J F Dopheide (Mainz,DE), M Scheer (Mainz,DE), V Obst (Mainz,DE), C Doppler (Mainz,DE), M P Radsak (Mainz,DE), T Gori (Mainz,DE), A Warnholtz (Mainz,DE), A Daiber (Mainz,DE), T F Munzel (Mainz,DE), C Espinola-Klein (Mainz,DE)

J.F. Dopheide1 , M. Scheer1 , V. Obst1 , C. Doppler1 , M.P. Radsak1 , T. Gori1 , A. Warnholtz1 , A. Daiber1 , T.F. Munzel1 , C. Espinola-Klein1 , 1University Hospital of Mainz - Mainz - Germany ,

European Heart Journal ( 2013 ) 34 ( Abstract Supplement ), 1090

Background: Atherosclerosis is sustained by chronic inflammation and reactive oxygen species (ROS). Monocytes are involved in this inflammatory process. The aim of the study was to test whether even non-supervised exercise training can ameliorate proinflammation.

Methods: 60 patients with peripheral arterial disease (PAD) with intermittent claudicatio (IC, Fontaine State II a and b) performed a non-supervised exercise training. Leukocytes were analysed from whole blood by flow cytometry (FACS-Canto, bd-biosciences). Monocytes were analysed for CD14/ CD16, M-DC8, CD86, CD11 b/c. ROS formation was determined by chemiluminescence (L-012 ECL) assays in whole blood after addition of phorbol-12,13-dibutyrate (PDBu). CRP, fibrinogen, ankle-brachial-index (ABI) and walking distance were analysed after standard protocol. Follow-up was performed after 12 months.

Results: After 12 months training, we observed a shift towards a significant increased proportion of antiinflammtory CD14++CD16+ monocytes (p<0.001), paralleled by a decrease in proinflammatory CD14-CD16++ and M-DC8+ monocytes (both p<0.001). Expression of CD86, CD11b/c (all p<0.01), as well as ROS production by PDBu decreased after 12 months (p<0.05). CRP and fibrinogen did not differ. However, ABI increased (p< 0.05), as well as the absolute walking distance (mean 145 m; p<0.05).

Conclusions: PAD patients, even under non-supervised exercise training for 12 months, show a decreased proinflammatory phenotype on monocytes and a decreased ROS production parallel to an increased walking distance. Here, we show in vivo insights in the process of atherogenesis of patients with intermittent claudication indicating an amelioration of the disease through anti-inflammatory strategies, i.e. exercise training.

Figure 1

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