In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.

Member Benefit

This content is only available year-round to ESC Professional Members, Fellows of the ESC, and Young Combined Members

Myocardial iron overload in sickle/thalassemia patients of Italian origin

Session Poster Session 4

Speaker Antonella Meloni

Event : ESC Congress 2013

  • Topic : imaging
  • Sub-topic : Cardiac Magnetic Resonance (CMR)
  • Session type : Poster Session

Authors : A Meloni (Pisa,IT), L Gulino (Pisa,IT), G Ruffo (Palermo,IT), PMG Sanna (Nuoro,IT), A Quarta (Brindisi,IT), D De Marchi (Pisa,IT), G Valeri (Ancona,IT), P Preziosi (Roma,IT), M Lombardi (Pisa,IT), A Pepe (Pisa,IT)

Authors:
A. Meloni1 , L. Gulino1 , G. Ruffo2 , P.M.G. Sanna3 , A. Quarta4 , D. De Marchi1 , G. Valeri5 , P. Preziosi6 , M. Lombardi1 , A. Pepe1 , 1CMR Unit, Fondazione G.Monasterio CNR-Regione Toscana and Institute of Clinical Physiology - Pisa - Italy , 2U.O.C. Ematologia con Talassemia ARNAS Ospedale Civico - Palermo - Italy , 3San Francesco Hospital, Service of Immunohaematology and Transfusion Medicine - Nuoro - Italy , 4A. Perrino Hospital, Department of Hematology - Brindisi - Italy , 5Dip. Materno/Infantile Osp. Engles Profili - Ancona - Italy , 6U.O.C. Diagnostica per Immagini e Interventistica Policlinico Casilino - Roma - Italy ,

Topic(s):
Cardiovascular Magnetic Resonance (CMR)

Citation:
European Heart Journal ( 2013 ) 34 ( Abstract Supplement ), 518

Purpose: Sickle-thalassemia is an inherited hemoglobin disorder resulting from the combined heterozygosity for sickle-cell and β-thalassemia genes. Myocardial iron overload in patients with sickle-thalassemia has been poorly studied; however, a report has shown no evidence of cardiac iron in a small group (n=10) of multitransfused Arab patients. The current study aims to further evaluate cardiac iron overload in a larger group of Italian patients using a T2* multislice approach and explore its correlation with transfusions, age and sex.

Methods: Fifty-nine sickle-thalassemia patients (29 males, mean age 35.6±14.1 years), enrolled in the MIOT network were considered. Three parallel short-axis views of the left ventricle were acquired and analyzed with a dedicated software (HIPPO MIOT) providing the T2* value on each of 16 segments as well as the global T2* value averaged over all segmental T2* values and the T2* value in the mid-ventricular segment averaged over the mid-anterior and the mid-inferior septum.

Results: We found 55 (93%) patients with all 16 segmental T2* values normal (>20 ms). Of the 4 patients with abnormal segmental T2* values, all showed an heterogeneous MIO (some segments with T2* values >20 ms and other segments with T2* values <20 ms) and none showed an homogeneous MIO (all segment with T2* values <20 ms). Out of the 4 patients with heterogeneous MIO, only one had a global T2* global <20 ms.

The mean global heart T2* value was 34.4±6.2 ms.

We did not find significant differences among sickle-thalassemia regularly (N=20), sporadically (N=32) and no transfused (N=7) in the T2* global value (33.4±7.3 ms versus 35.5±5.4 ms versus 32.4±6.3 ms; P=0.425).

On linear regression analysis, there was a statistically significant positive correlation between global T2* and age but with poor linearity (R=0.368; P=0.004).

The global T2* value was not significant different between males and females (35.6±4.9 ms versus 35.2±7.2 ms; P=0.118).

Conclusions: In respect of myocardial iron deposition, the sickle/thalassemia patients are similar to patients with homozygous SCD for which iron overloading is relatively rare.

Member Benefit

This content is only available year-round to ESC Professional Members, Fellows of the ESC, and Young Combined Members

Get your access to resources

Join now
  • 1ESC Professional Members – access all ESC Congress resources 
  • 2ESC Association Members (Ivory, Silver, Gold) – access your Association’s resources
  • 3Under 40 or in training - with a Combined Membership, access all resources
Join now
logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are