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Association of type 2 diabetes with leukocyte telomere length and cardiovascular aging

Session Poster Session 3

Speaker Ekaterina Plokhova

Event : ESC Congress 2013

  • Topic : heart failure
  • Sub-topic : Diastolic Ventricular Dysfunction
  • Session type : Poster Session

Authors : E V Plokhova (Moscow,RU), ON Tkacheva (Moscow,RU), DU Akasheva (Moscow,RU), ID Strazhesko (Moscow,RU), AS Kruglikova (Moscow,RU), EN Dudinskaya (Moscow,RU), SA Boytsov (Moscow,RU)

E.V. Plokhova1 , O.N. Tkacheva1 , D.U. Akasheva1 , I.D. Strazhesko1 , A.S. Kruglikova1 , E.N. Dudinskaya1 , S.A. Boytsov1 , 1National Center of Preventive Medicine - Moscow - Russian Federation ,

European Heart Journal ( 2013 ) 34 ( Abstract Supplement ), 452

Purpose: Telomeres are the regions at the ends of the chromosomes and consist of DNA repeat sequence. Leukocyte telomere length (TL) is shortened with each cell division and may trigger growth arrest and cellular senescence. With aging, increased apoptosis of cardiomyocytes leads to cardiac remodeling and left ventricular (LV) failure. Shortened TL has been observed in type 2 diabetes. We suggest that heart aging may be associated with diabetes mellitus through cellular mechanisms senescence.

Methods: In a group of 154 healthy people, aged 25 to 75 years, we measured LV mass by two-dimensional area-length method, LV mass index and LV diastolic function (E/A ratio, DTE) using Doppler echocardiography. The LTL was measured by real-time quantitative polymerase chain reaction. All the participants were defined the level of NT-Pro BNP in plasma. Diabetes mellitus determined by use of hypoglycemic agents or fasting glucose ≥ 126 mg/dL. The people were divided into 2 groups: "without diabetes" and "with diabetes". We compared the signs of left ventricular diastolic function and LTL between the two groups. These groups were compatible in sex and hypertension.

Results: See Table 1.

Conclusions: The present data suggest that diabetes mellitus is associated with the presence of shorter LTL and signs of aging heart (increased LV mass and diastolic dysfunction of the left ventricle). Thus, diabetes is associated with cellular senescence and contributes to age-related changes of the heart.

Table 1
Without diabetes (n=106)With diabetes (n=49)P value
Mean ± mMean ± m
Age, y49,5±2,268,2±1,80,001
Telomere length9,97±0,149,32±0,120,02
LV mass index, g/m283,4±4,198,2±3,80,05
E/A ratio1,2±0,030,86±0,020,02
DTE, ms180,3±7,5221,2±16,40,08
NT-Pro BNP, pg/ml76,4±12,5168,4±43,20,01
Abbreviations: LV, left ventricular; E/A ratio, peak velocity of early transmitral inflow (E)-to-peak velocity of late transmitral inflow (A) ratio; DTE, decelaration time of the E wave.

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