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Serum omentin significantly predicts cardiovascular events both in patients with the metabolic syndrome and in subjects who do not have the metabolic syndrome

Session Poster Session 1

Speaker Christoph Saely

Event : ESC Congress 2013

  • Topic : preventive cardiology
  • Sub-topic : Obesity
  • Session type : Poster Session

Authors : CH Saely (Fedlkirch,AT), A Leiherer (Feldkirch,AT), A Muendlein (Feldkirch,AT), A Vonbank (Triesen,LI), D Zanolin (Feldkirch,AT), K Geiger (Feldkirch,AT), H Drexel (Philadelphia,US)

C.H. Saely1 , A. Leiherer2 , A. Muendlein2 , A. Vonbank3 , D. Zanolin2 , K. Geiger2 , H. Drexel4 , 1Academic Teaching Hospital, Department of Internal Medicine - Fedlkirch - Austria , 2VIVIT Institute - Feldkirch - Austria , 3Private University of the Principality of Liechtenstein - Triesen - Liechtenstein , 4Drexel University College of Medicine - Philadelphia - United States of America ,

European Heart Journal ( 2013 ) 34 ( Abstract Supplement ), 143-144

Purpose: Some recent small cross-sectional studies have described associations of the novel adipocytokine omentin with atherosclerosis. However, no prospective data on the power of omentin to predict cardiovascular events are available.

Methods: We therefore measured serum omentin in a series of 297 patients undergoing coronary angiography for the evaluation of established or suspected stable CAD; the metabolic syndrome (MetS) was defined according to national cholesterol education programme adult treatment panel III criteria; cardiovascular events were recorded over a mean follow-up period of 3.2 years.

Results: During the follow-up period, 18.4% of our patients suffered cardiovascular events, corresponding to an annual event rate of 5.8%. In the total study population, serum omentin significantly predicted cardiovascular events both univariately (standardized adjusted HR 1.47 [1.21-1.78]; p <0.001) and after adjustment for age, gender, BMI, diabetes, hypertension, LDL cholesterol, HDL cholesterol and smoking (HR 1.49 [1.21-1.82]; p<0.001). From our patients, 98 had the MetS and 199 did not have the MetS. In both of these patient subgroups serum omentin strongly predicted cardiovascular events both univariately (HRs 1.51 [1.15-2.00]; p=0.003 and 1.41 [1.08-1.84]; p=0.011, respectively) and after adjustment for age, gender, BMI, diabetes, hypertension, LDL cholesterol, HDL cholesterol and smoking (1.56 [1.09-2.25]; p=0.016 and 1.48 [1.12-1.97]; p=0.006, respectively).

Conclusions: From this first prospective evaluation of the cardiovascular risk associated with serum omentin we conclude that elevated serum omentin is a strong predictor of cardiovascular events both among patients with the MetS and among subjects who do not have the MetS.

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