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Clinical impact of antithrombotic therapy in transvenous lead extraction complications: a sub-analysis from the ESC-EHRA ELECTRa (European Lead Extraction ConTRolled) Registry

Session Top of the pops in arrhythmia treatment - from life-style modification to lead extraction

Speaker Doctor Andrea Di Cori

Event : ESC Congress 2019

  • Topic : arrhythmias and device therapy
  • Sub-topic : Device Complications and Lead Extraction
  • Session type : Abstract Sessions

Authors : A Di Cori (Pisa,IT), A Auricchio (Lugano,CH), F Regoli (Lugano,CH), C Blomstrom-Lundqvist (Uppsala,SE), C Butter (Bernau bei Berlin,DE), N Dagres (Leipzig,DE), JC Deharo (Marseille,FR), AP Maggioni (Sophia Antipolis,FR), A Kutarski (Lublin,PL), C Kennergren (Goteborg,SE), C Laroche (Sophia Antipolis,FR), CA Rinaldi (London,GB), PG Golzio (Turin,IT), AM Thogersen (Aalborg,DK), MG Bongiorni (Pisa,IT)

A. Di Cori1 , A. Auricchio2 , F. Regoli2 , C. Blomstrom-Lundqvist3 , C. Butter4 , N. Dagres5 , J.C. Deharo6 , A.P. Maggioni7 , A. Kutarski8 , C. Kennergren9 , C. Laroche7 , C.A. Rinaldi10 , P.G. Golzio11 , A.M. Thogersen12 , M.G. Bongiorni1 , 1Azienda Ospedaliero-Universitaria Pisana, Cardiac-Thoracic and Vascular Department - Pisa - Italy , 2Cardiocentro Ticino - Lugano - Switzerland , 3Uppsala University, Department of Medical Science and Cardiology - Uppsala - Sweden , 4Brandenburg Heart Center, Department of Cardiology - Bernau bei Berlin - Germany , 5Heart Center of Leipzig, Department of Electrophysiology - Leipzig - Germany , 6Hospital La Timone of Marseille - Marseille - France , 7EURObservational Research Programme (EORP), European Society of Cardiology - Sophia Antipolis - France , 8Medical University of Lublin, Department of Cardiology - Lublin - Poland , 9Sahlgrenska Academy - University of Gothenburg - Goteborg - Sweden , 10St Thomas' Hospital - London - United Kingdom , 11Hospital Città della Salute e della Scienza di Torino, Deptartment of Internal Medicine - Turin - Italy , 12Aalborg University Hospital - Aalborg - Denmark ,

On behalf: ESC-EHRA ELECTRa Investigators

Device Complications and Lead Extraction

European Heart Journal ( 2019 ) 40 ( Supplement ), 3653

Introduction: The complexity of candidates for transvenous lead extraction (TLE) has shown a parallel increase, both in terms of comorbidities, and of concomitant therapy, including antithrombotic therapy (AT). The management of candidates for TLE receiving concomitant AT is a debated issue, and only marginally the object of evidence-based recommendations in current guidelines. The ESC-EHRA European Lead Extraction ConTRolled Registry (ELECTRa) is a prospective registry of consecutive TLE procedures conducted by the European Heart Rhythm Association (EHRA) in order to identify the safety and efficacy of the current practice of TLE.

Purpose: The present study is a sub-analysis of the ESC-EHRA ELECTRa Registry conducted with the aim of evaluating the clinical impact of AT on TLE safety and efficacy.

Methods: All consecutive TLE patients enrolled in the ELECTRa registry were included. Success rate and procedural-related complications, including death, were compared between patients without AT therapy (No AT Group) and with different pre-operative AT regimens (AT subgroups), including antiplatelets (AP), anticoagulants (AC) or both (AP + AC).

Results: Out of 3510 TLE pts, 2398 (68%) were under AT pre-operatively. AT patients were older with more co-morbidities (p<0.0001). AT subgroups, defined as AP, AC or AP+AC, were 1096 (31.2%), 985 (28%) and 317 (9%), respectively. Regarding AP patients, 1413 (40%) were under AP, 1292 (91%) with a single AP and 121 (9%) with a dual AP therapy. AP was interrupted in 26% of pts 3.8±3.7 days before TLE. Regarding AC patients, 1302 (37%) patients were under AC,881 were under VKA (68%), 221 (17%) under DOAC, 155 (12%) under LWMH and 45 (3.5%) under UFH.AC pre-procedural management strategy included “interruption without bridging” in 696 (54%), “interruption with bridging” in 504 (39%) and a “continued” strategy in 87 (7%). AC was interrupted about 3.3±2.3 days before TLE.

TLE clinical success rate was high (98%) in all subgroups. Only the incidence of overall death (1.4%), but not the procedure-related, was higher in the AT subgroups (p=0.0500). (Figure A) Age >65 years and NYHA Class III/IV, but not AT regimens, were independent predictors of death for any cause.

Regarding minor complications, hematomas were more frequently observed between AC “continued” patients (p=0.025), whereas pulmonary embolism in the No-AT group (p<0.01). (Figure B)

Conclusions: The AT subgroups showed a comparable TLE success rate, with a higher in-hospital, but non intra-procedural, mortality and more minor bleedings compared to no-ATs. Neither AT regimens or pre-procedural management strategies predicted major complications. AT therapy minimization seems to be safe in patients under chronic AT therapy who undergo TLE. AT do not seem to predict death but identifies a subset of fragile patients with a worse in-hospital TLE outcome.

Figure A and B

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