In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.


This content is currently on FREE ACCESS, enjoy another 47 days of free consultation

 

Relationship between skin autofluorescence levels and clinical outcomes in heart failure patients undergoing cardiac rehabilitation

Session Poster Session 7

Speaker Mitsuhiro Kunimoto

Congress : ESC Congress 2019

  • Topic : preventive cardiology
  • Sub-topic : Risk Factors and Prevention - Cardiovascular Risk Assessment
  • Session type : Poster Session
  • FP Number : P6209

Authors : M Kunimoto (Tokyo,JP), K Shimada (Tokyo,JP), M Yokoyama (Tokyo,JP), A Honzawa (Tokyo,JP), M Yamada (Tokyo,JP), T Matsubara (Tokyo,JP), K Fukao (Tokyo,JP), T Kadoguchi (Tokyo,JP), K Fujiwara (Tokyo,JP), T Miyazaki (Tokyo,JP), T Yamamoto (Tokyo,JP), T Takahashi (Tokyo,JP), T Fujiwara (Tokyo,JP), A Amano (Tokyo,JP), H Daida (Tokyo,JP)

Authors:
M Kunimoto1 , K Shimada1 , M Yokoyama1 , A Honzawa2 , M Yamada2 , T Matsubara1 , K Fukao1 , T Kadoguchi3 , K Fujiwara1 , T Miyazaki1 , T Yamamoto4 , T Takahashi5 , T Fujiwara6 , A Amano4 , H Daida1 , 1Juntendo University School of Medicine, Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine - Tokyo - Japan , 2Juntendo University School of Medicine, Cardiovascular Rehabilitation and Fitness - Tokyo - Japan , 3Juntendo University School of Medicine, Sportology Center, Juntendo University Graduate School of Medicine - Tokyo - Japan , 4Juntendo University School of Medicine, Department of Cardiovascular Surgery, Juntendo University Graduate School of Medicine - Tokyo - Japan , 5Juntendo University, Department of Physical Therapy, Faculty of Health Sciences - Tokyo - Japan , 6Juntendo University School of Medicine, Department of Rehabilitation Medicine, Juntendo University Graduate School of Medicine - Tokyo - Japan ,

Citation:

Background
Advanced glycation end-products, indicated by skin autofluorescence (SAF) levels, could be prognostic predictors of all-cause and cardiovascular mortality in patients with diabetes mellitus (DM) and renal disease. However, the clinical usefulness of SAF levels in patients with heart failure (HF) who underwent cardiac rehabilitation (CR) remains unclear.
Purpose
The purpose of this study was to investigate the prognostic value of SAF levels in patients with HF who underwent CR.
Methods
This study enrolled 204 consecutive patients with HF who had undergone CR at our university hospital between November 2015 and October 2017. Clinical characteristics and anthropometric data were collected at the beginning of CR. SAF levels were noninvasively measured with an autofluorescence reader. The major adverse cardiovascular event (MACE) was a composite of all-cause mortality and unplanned hospitalization for HF. Follow-up data concerning primary endpoints were collected until November 2018.
Results
Patients’ mean age was 68.1 years, and 61% were males. Patients were divided into two groups according to the median SAF levels (high and low SAF groups). Patients in the high SAF group were significantly older, had a higher prevalence of chronic kidney disease, and histories of coronary artery bypass surgery; however, there were no significant between-group differences in sex, prevalence of DM, left ventricular ejection fraction, and physical function. During a median follow-up period of 623 days, 25 patients experienced all-cause mortality and 34 were hospitalized for HF. Kaplan–Meier analysis showed that patients in the high SAF group had a higher incidence of MACE (log-rank P < 0.05), whereas when patients were divided into two groups according to the median hemoglobin A1c level, no significant between-group difference was observed for the incidence of MACE (Figure). After adjusting for confounding factors, Cox regression multivariate analysis revealed that SAF levels were independently associated with the incidence of MACE (hazard ratio: 1.74, 95% confidence interval: 1.12–2.65, P < 0.05).
Conclusion
SAF levels were significantly associated with the incidence of MACE in patients with HF and may be useful for risk stratification in patients with HF who undergo CR.



Based on your interests

Members get more

Join now
  • 1ESC Professional Members – access all resources from ESC Congress and ESC Asia with APSC & AFC
  • 2ESC Association Members (Ivory, Silver, Gold) – access your Association’s congress resources
  • 3Under 40 or in training - with a Combined Membership, access resources from all congresses
Join now

Our sponsors

ESC 365 is supported by Bayer, Boehringer Ingelheim and Lilly Alliance, Bristol-Myers Squibb and Pfizer Alliance, Novartis Pharma AG and Vifor Pharma in the form of educational grants. The sponsors were not involved in the development of this platform and had no influence on its content.

logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are