In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.


This content is currently on FREE ACCESS, enjoy another 104 days of free consultation

 

prognostic value of non-obstructive coronary artery disease detected on coronary computed tomography angiography among subjects with suspected coronary artery disease

Session Poster Session 7

Speaker Ahmed Aljizeeri

Congress : ESC Congress 2019

  • Topic : imaging
  • Sub-topic : Coronary CT Angiography
  • Session type : Poster Session
  • FP Number : P6158

Authors : A Aljizeeri (Riyadh,SA), M Alali Alfaris (Riyadh,SA), D Ahmed (Riyadh,SA), J Farea (Riyadh,SA), A Elneama (Riyadh,SA), I Suliman (Riyadh,SA), A Ahmed (Riyadh,SA), M Alharthi (Riyadh,SA), A Alsaileek (Riyadh,SA), M Al-Mallah (Houston,US)

Authors:
A Aljizeeri1 , M Alali Alfaris1 , D Ahmed1 , J Farea1 , A Elneama1 , I Suliman1 , A Ahmed1 , M Alharthi1 , A Alsaileek1 , M Al-Mallah2 , 1King Abdulaziz Medical City-Riyadh - Riyadh - Saudi Arabia , 2The Methodist Hospital - Houston - United States of America ,

Citation:

Introduction:

Coronary Computed Tomography Angiography (CTA) is an established technique for the detection of coronary artery disease (CAD). However, the prognostic value of non-obstructive CAD is not well defined. Thus, the aim of this analysis is to determine the prognostic value of non-obstructive CAD detected on CTA.

Methods:

In the Multi-Center Multi-Ethnic Coronary Computed Tomography Angiography (MECCA) Study, 3209 subjects without known CAD underwent CTA. Patients with obstructive CAD were excluded from this analysis.  Patients with = 70% luminal coronary artery stenosis in vessels other than the left main were classified to have non-obstructive CAD while patients without any plaque were considered to have normal CTA. Patients were followed up for a median duration of 3.4 years for all-cause mortality (ACM). Multivariable Cox models were used to determine the independent predictors of event-free survival.

Results:

A total of 1455 subjects had non-obstructive CAD and 1382 subjects had normal coronary arteries. Subjects with non-obstructive CAD were older (55.9±11 vs 46.2±11 years, p<0.001) and more likely to be males (56.8% vs 50.5%, p=0.001) and had more prevalent traditional risk factors. A total of 83 ACM were observed (4.4% in the non-obstructive group and 1.3% in the normal group, p<0.001). Patients with clinical events were older (61.8±14 vs 50.9±12 years, p<0.001) and have more prevalence of DM(42.2% vs 31.4%, p=0.031)  and HTN (72.3% vs 54.3%, p=0.001). In Multivariable Cox models, non-obstructive CAD was associated with increased event rate ( Hazard ratio 1.75, 95% CI 1.01 – 3.01, p=0.45).

Conclusions:

Patients with non-obstructive CAD on CTA have a higher rate of all-cause mortality. Non-obstructive CAD on CTA enhances risk stratification among subjects suspected with CAD and should call for more aggressive guidelines directed medical therapy.

This content is currently on FREE ACCESS, enjoy another 104 days of free consultation

 



Based on your interests

Three reasons why you should become a member

Become a member now
  • 1Access your congress resources all year-round on the New ESC 365
  • 2Get a discount on your next congress registration
  • 3Continue your professional development with free access to educational tools
Become a member now

Our sponsors

ESC 365 is supported by Bayer, Boehringer Ingelheim and Lilly Alliance, Bristol-Myers Squibb and Pfizer Alliance, Novartis Pharma AG and Vifor Pharma in the form of educational grants. The sponsors were not involved in the development of this platform and had no influence on its content.

logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are