Background: There are limited comparative data concerning long-term major clinical outcomes between male and female in dyslipidemic AMI patients after PCI with new-generation DES.
Purpose: We thought to investigate the impact of gender difference on the 2-year clinical outcomes.
Methods: Finally, a total of 2403 eligible dyslipidemic AMI patients who underwent PCI with new-generation DES were enrolled and they were separated into two groups; the male group (n = 1800) and the female group (n = 603). The primary endpoint was major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), target lesion revascularization (TLR), and target vessel revascularization (TVR). The secondary endpoints were the incidence of the individual components of MACE and target vessel failure (TVF), a composite of death related to the target vessel, re-MI, or clinically driven TVR
Results: Two propensity score-matched (PSM) groups (422 pairs, n = 844, C-statistic = 0.850) were generated. In the total study population, the cumulative incidences of MACE, all-cause death, re-MI, and TVF were significantly higher in the female group compared with the male group. However, after propensity score-matched (PSM) analysis, the cumulative incidences of MACE (HR, 0.971; 95% CI, 0.628–1.501; p = 0.895), all-cause death (HR, 1.061; 95% CI, 0.536–2.100; p = 0.865), re-MI (HR, 1.212; 95% CI, 0.433–2.907; p = 0.813), and TVF (HR, 0.764; 95% CI, 0.474–1.229; p = 0.267) were similar between the two groups. In addition, the cumulative incidences of cardiac death, TLR, TVR were not significantly different between the two groups (Table 1).
Conclusion: The gender difference was not apparent in these dyslipidemic South Korean AMI patients who underwent PCI with new-generation DES during 2-year follow-up period.
Purpose: We thought to investigate the impact of gender difference on the 2-year clinical outcomes.
Methods: Finally, a total of 2403 eligible dyslipidemic AMI patients who underwent PCI with new-generation DES were enrolled and they were separated into two groups; the male group (n = 1800) and the female group (n = 603). The primary endpoint was major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), target lesion revascularization (TLR), and target vessel revascularization (TVR). The secondary endpoints were the incidence of the individual components of MACE and target vessel failure (TVF), a composite of death related to the target vessel, re-MI, or clinically driven TVR
Results: Two propensity score-matched (PSM) groups (422 pairs, n = 844, C-statistic = 0.850) were generated. In the total study population, the cumulative incidences of MACE, all-cause death, re-MI, and TVF were significantly higher in the female group compared with the male group. However, after propensity score-matched (PSM) analysis, the cumulative incidences of MACE (HR, 0.971; 95% CI, 0.628–1.501; p = 0.895), all-cause death (HR, 1.061; 95% CI, 0.536–2.100; p = 0.865), re-MI (HR, 1.212; 95% CI, 0.433–2.907; p = 0.813), and TVF (HR, 0.764; 95% CI, 0.474–1.229; p = 0.267) were similar between the two groups. In addition, the cumulative incidences of cardiac death, TLR, TVR were not significantly different between the two groups (Table 1).
Conclusion: The gender difference was not apparent in these dyslipidemic South Korean AMI patients who underwent PCI with new-generation DES during 2-year follow-up period.
