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Impact of the gender difference on long-term clinical outcomes in dyslipidemic South Korean AMI patients who underwent PCI with new-generation DES

Session Poster Session 6

Speaker Yong Hoon Kim

Event : ESC Congress 2019

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Coronary Artery Disease – Epidemiology, Prognosis, Outcome
  • Session type : Poster Session

Authors : YH Kim (Chuncheon,KR), A-Y Her (Chuncheon,KR), M-H Jeong (Gwangju,KR), B-K Kim (Seoul,KR), S-Y Lee (Gunpo,KR), S-J Hong (Seoul,KR), D-H Shin (Seoul,KR), C-M Ahn (Seoul,KR), J-S Kim (Seoul,KR), Y-G Ko (Seoul,KR), D Choi (Seoul,KR), M-K Hong (Seoul,KR), Y Jang (Seoul,KR)

Authors:
Y.H. Kim1 , A.-Y. Her1 , M.-H. Jeong2 , B.-K. Kim3 , S.-Y. Lee4 , S.-J. Hong3 , D.-H. Shin3 , C.-M. Ahn3 , J.-S. Kim3 , Y.-G. Ko3 , D. Choi3 , M.-K. Hong3 , Y. Jang3 , 1Kangwon National University School of Medicine - Chuncheon City - Korea (Republic of) , 2Chonnam National University Hospital, Department of Cardiology - Gwangju - Korea (Republic of) , 3Severance Cardiovascular Hospital, Division of Cardiology, Yonsei University College of Medicine - Seoul - Korea (Republic of) , 4Sanbon Hospital, Wonkwang University College of Medicine, Department of Cardiology - Gunpo - Korea (Republic of) ,

Topic(s):
Coronary Artery Disease – Epidemiology, Prognosis, Outcome

Citation:
European Heart Journal ( 2019 ) 40 ( Supplement ), 3373

Background: There are limited comparative data concerning long-term major clinical outcomes between male and female in dyslipidemic AMI patients after PCI with new-generation DES.

Purpose: We thought to investigate the impact of gender difference on the 2-year clinical outcomes.

Methods: Finally, a total of 2403 eligible dyslipidemic AMI patients who underwent PCI with new-generation DES were enrolled and they were separated into two groups; the male group (n=1800) and the female group (n=603). The primary endpoint was major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), target lesion revascularization (TLR), and target vessel revascularization (TVR). The secondary endpoints were the incidence of the individual components of MACE and target vessel failure (TVF), a composite of death related to the target vessel, re-MI, or clinically driven TVR

Results: Two propensity score-matched (PSM) groups (422 pairs, n=844, C-statistic = 0.850) were generated. In the total study population, the cumulative incidences of MACE, all-cause death, re-MI, and TVF were significantly higher in the female group compared with the male group. However, after propensity score-matched (PSM) analysis, the cumulative incidences of MACE (HR, 0.971; 95% CI, 0.628–1.501; p=0.895), all-cause death (HR, 1.061; 95% CI, 0.536–2.100; p=0.865), re-MI (HR, 1.212; 95% CI, 0.433–2.907; p=0.813), and TVF (HR, 0.764; 95% CI, 0.474–1.229; p=0.267) were similar between the two groups. In addition, the cumulative incidences of cardiac death, TLR, TVR were not significantly different between the two groups (Table 1).

Conclusion: The gender difference was not apparent in these dyslipidemic South Korean AMI patients who underwent PCI with new-generation DES during 2-year follow-up period.

OutcomesCumulative Events at 2-year (%)Hazard Ratio (95% CI)p value
MaleFemaleLog-rank
Propensity score matched patients
MACE41 (10.4)40 (10.3)0.8950.971 (0.628–1.501)0.895
All-cause death16 (4.0)17 (4.2)0.8651.061 (0.536–2.100)0.865
Cardiac death13 (3.3)9 (2.2)0.3910.691 (0.295–1.616)0.393
Re-MI8 (2.0)9 (2.4)0.8131.212 (0.433–2.907)0.813
TLR7 (1.8)6 (1.6)0.7810.857 (0.298–2.550)0.781
TVR16 (4.3)10 (2.7)0.2360.623 (0.283–1.373)0.241
TVF39 (10.2)30 (7.8)0.2650.764 (0.474–1.229)0.267

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