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Impact of the gender difference on long-term clinical outcomes in dyslipidemic South Korean AMI patients who underwent PCI with new-generation DES
Authors : YH Kim (Chuncheon,KR), A-Y Her (Chuncheon,KR), M-H Jeong (Gwangju,KR), B-K Kim (Seoul,KR), S-Y Lee (Gunpo,KR), S-J Hong (Seoul,KR), D-H Shin (Seoul,KR), C-M Ahn (Seoul,KR), J-S Kim (Seoul,KR), Y-G Ko (Seoul,KR), D Choi (Seoul,KR), M-K Hong (Seoul,KR), Y Jang (Seoul,KR)
YH Kim1
,
A-Y Her1
,
M-H Jeong2
,
B-K Kim3
,
S-Y Lee4
,
S-J Hong3
,
D-H Shin3
,
C-M Ahn3
,
J-S Kim3
,
Y-G Ko3
,
D Choi3
,
M-K Hong3
,
Y Jang3
,
1Kangwon National University School of Medicine - Chuncheon - Korea (Republic of)
,
2Chonnam National University Hospital, Department of Cardiology - Gwangju - Korea (Republic of)
,
3Severance Cardiovascular Hospital, Division of Cardiology, Yonsei University College of Medicine - Seoul - Korea (Republic of)
,
4Sanbon Hospital, Wonkwang University College of Medicine, Department of Cardiology - Gunpo - Korea (Republic of)
,
Citation:
Background: There are limited comparative data concerning long-term major clinical outcomes between male and female in dyslipidemic AMI patients after PCI with new-generation DES.
Purpose: We thought to investigate the impact of gender difference on the 2-year clinical outcomes.
Methods: Finally, a total of 2403 eligible dyslipidemic AMI patients who underwent PCI with new-generation DES were enrolled and they were separated into two groups; the male group (n = 1800) and the female group (n = 603). The primary endpoint was major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), target lesion revascularization (TLR), and target vessel revascularization (TVR). The secondary endpoints were the incidence of the individual components of MACE and target vessel failure (TVF), a composite of death related to the target vessel, re-MI, or clinically driven TVR
Results: Two propensity score-matched (PSM) groups (422 pairs, n = 844, C-statistic = 0.850) were generated. In the total study population, the cumulative incidences of MACE, all-cause death, re-MI, and TVF were significantly higher in the female group compared with the male group. However, after propensity score-matched (PSM) analysis, the cumulative incidences of MACE (HR, 0.971; 95% CI, 0.628–1.501; p = 0.895), all-cause death (HR, 1.061; 95% CI, 0.536–2.100; p = 0.865), re-MI (HR, 1.212; 95% CI, 0.433–2.907; p = 0.813), and TVF (HR, 0.764; 95% CI, 0.474–1.229; p = 0.267) were similar between the two groups. In addition, the cumulative incidences of cardiac death, TLR, TVR were not significantly different between the two groups (Table 1).
Conclusion: The gender difference was not apparent in these dyslipidemic South Korean AMI patients who underwent PCI with new-generation DES during 2-year follow-up period.
ESC 365 is supported by Bayer, Boehringer Ingelheim and Lilly Alliance, Bristol-Myers Squibb and Pfizer Alliance, Novartis Pharma AG and Vifor Pharma in the form of educational grants. The sponsors were not involved in the development of this platform and had no influence on its content.
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