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Current smoking and gender difference in South Korean AMI patients who underwent PCI with DES
Authors : YH Kim (Chuncheon,KR), A-Y Her (Chuncheon,KR), MH Jeong (Gwangju,KR), B-K Kim (Seoul,KR), S-Y Lee (Gunpo,KR), S-J Hong (Seoul,KR), D-H Shin (Seoul,KR), C-M Ahn (Seoul,KR), J-S Kim (Seoul,KR), Y-G Ko (Seoul,KR), D Choi (Seoul,KR), M-K Hong (Seoul,KR), Y Jang (Seoul,KR)
YH Kim1
,
A-Y Her1
,
MH Jeong2
,
B-K Kim3
,
S-Y Lee4
,
S-J Hong3
,
D-H Shin3
,
C-M Ahn3
,
J-S Kim3
,
Y-G Ko3
,
D Choi3
,
M-K Hong3
,
Y Jang3
,
1Kangwon National University School of Medicine - Chuncheon - Korea (Republic of)
,
2Chonnam National University Hospital, Department of Cardiology - Gwangju - Korea (Republic of)
,
3Severance Cardiovascular Hospital, Division of Cardiology, Yonsei University College of Medicine - Seoul - Korea (Republic of)
,
4Sanbon Hospital, Wonkwang University College of Medicine, Department of Cardiology - Gunpo - Korea (Republic of)
,
Citation:
Background: There is some debate on whether or not there is a gender difference is present between current smoking and cardiovascular disease.
Purpose: We decide to evaluate the impact of sex difference on the 2-year clinical outcomes in Korean acute myocardial infarction (AMI) patients who currently smoke and who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES).
Methods: The data of this study was obtained from the Korea Acute Myocardial Infarction (KAMIR) registry. More than fifty high-volume universites or community hospitals with facilities for primary PCI and onsite cardiac surgery participated in this KAMIR registry. A total of 12565 current smoker AMI patients were enrolled and divided into the male (n= 11767, 93.6%) or female (n = 798, 6.4%) group. The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), and total repeat revascularization.
Results: Before risk adjustment, the cumulative incidences of MACE (7.2% vs. 10.0%, hazard ratio [HR], 1.419; 95% confidence interval [CI], 1.125-1.790; P = 0.003), all-cause death (HR, 1.988; 95% CI, 1.417-2.789; P < 0.001), and re-MI (HR, 1.885; 95% CI, 1.154-3.078; P = 0.011) were significantly higher in the female group compared with the male group. However, after adjustment the cumulative incidences of MACE (adjusted HR, 1.047; 95% CI, 0.756–1.450; P = 0.782), all-cause death, re-MI, total repeat revascularization, TLR, TVR, and non-TVR were similar between the two groups.
Conclusion: Before risk adjustment, a gender difference was suggested in the female group compared with the male in these current smoker South Korean AMI patients during a 2-year follow-up period. However, after adjustment, gender difference was not observed in these AMI patients with a history of current smoking.
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