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Phrenic nerve injury during pulmonary vein isolation using the second-generation cryoballoon: characteristics and follow-up - The YETI registry

Session Managing electrical complications after Transcatheter Aortic Valve Implantation and other percutaneous arrhythmia procedures

Speaker Associate Professor Christian-Hendrik Heeger

Event : ESC Congress 2019

  • Topic : arrhythmias and device therapy
  • Sub-topic : Catheter Ablation of Arrhythmias
  • Session type : Rapid Fire Abstracts

Authors : CH Heeger (Luebeck,DE), A Pott (Ulm,DE), C Sohns (Bad Oeynhausen,DE), A Rillig (Hamburg,DE), M Kuniss (Bad Nauheim,DE), S Cay (Ankara,TR), S Miyazaki (Tsuchiura,JP), A Aryana (Sacramento,US), E Jedrzejczyk-Patej (Zabrze,PL), K Aytemir (Ankara,TR), O Inaba (Saitama,JP), JKR Chun (Frankfurt am Main,DE), P Sommer (Bad Oeynhausen,DE), T Dahme (Ulm,DE), RR Tilz (Luebeck,DE)

Authors:
C.H. Heeger1 , A. Pott2 , C. Sohns3 , A. Rillig4 , M. Kuniss5 , S. Cay6 , S. Miyazaki7 , A. Aryana8 , E. Jedrzejczyk-Patej9 , K. Aytemir10 , O. Inaba11 , J.K.R. Chun12 , P. Sommer3 , T. Dahme2 , R.R. Tilz1 , 1University of Luebeck, Medical clinic II - Luebeck - Germany , 2University of Ulm, Cardiology - Ulm - Germany , 3Heart and Diabetes Center NRW - Bad Oeynhausen - Germany , 4Asklepios Clinic St. Georg, Department of Cardiology - Hamburg - Germany , 5Kerckhoff Heart and Thorax Center - Bad Nauheim - Germany , 6Ankara Education and Research Hospital, Yuksek Ihtisas Heart-Education and Research Hospital - Ankara - Turkey , 7Tsuchiura Kyodo Hospital - Tsuchiura - Japan , 8Mercy Heart Institute - Sacramento - United States of America , 9Department of Cardiology, Congenital Heart Diseases and Electrotherapy - Zabrze - Poland , 10Hacettepe University - Ankara - Turkey , 11Red Cross Hospital - Saitama - Japan , 12CardioVascular Center Bethanien (CCB) - Frankfurt am Main - Germany ,

Citation:
European Heart Journal ( 2019 ) 40 ( Supplement ), 3735

Background: Second-generation cryoballoon (CB2) based pulmonary vein isolation (PVI) has emerged as a safe and effective treatment option for symptomatic atrial fibrillation (AF). Although published complication rates of CB2 based-PVI are relatively low and several safety algorithms have been implemented in the protocols the most frequent complication is right-sided phrenic nerve injury (PNI). The reported incidence of PNI varies from 2–5% of patients. However data on PNI characteristics as well as follow-up is sparse.

Purpose: We aimed to evaluate the incidence, characteristics and outcome of PNI during after CB2 based-PVI in a large patients population.

Methods and results: From July 2012 to November 2018 a total of 13693 patients received CB2 or CB3 (third-generation) based-PVI in 23 EP centers (Germany: 12, China: 1, Turkey: 3, Japan: 3, USA: 1, Austria: 1, Poland: 1, Swizerland: 1). A total of 596 (4.4%) of patients experienced PNI during treatment of the right superior (84%) right inferior (15%) right middle (0.3%) (and left superior (0.3%) pulmonary veins. The mean time to PNI was 127±51 seconds and the mean temperature at the time of PNI was −49±7 °C. The target PV was isolated at time of PNI in 84% of cases. The applications were interrupted using double-stop technique in (71%). In 212/306 (52%) a CMAP was utilized.

At the end of the procedure PNI persistent in 45% of patients. Fluoroscopic or sonographic evaluation of PNI was performed 1–3 days after the procedure and revealed persistent PNI in 35% of patients. Dyspnea before discharge was reported in 18% of patients with persistent PNI. Patients follow up at 1–3, and 6–12 months included fluoroscopy and a visit in an outpatient clinic. After 1–3 months 18% of patients showed persistent PNI including 13% of patients complaining of dyspnea. After 6–12 months of follow-up including fluoroscopic evaluation PNI was persistent in 1.8% of patients while dyspnea was reported by 1.7% patients. Only 0.08% of the overall population of 13693 patients showed permanent and symptomatic PNI.

Conclusion: The incidence of PNI during CB2-based PVI is low. About 55% of PNI recovered until the end of the procedure. Most of PNI recovered within 12 months. Symptomatic permanent PNI is very rare in patients after CB2/CB3-based PVI.

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