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Association with coronary high-intensity plaque on T1-weighted magnetic resonance imaging and circulating levels of malondialdehyde-modified low-density lipoprotein

Session Innovations in CMR for coronary artery disease

Speaker Daigo Hiraya

Event : ESC Congress 2019

  • Topic : imaging
  • Sub-topic : Cardiac Magnetic Resonance: Coronary Imaging
  • Session type : Moderated Posters

Authors : D Hiraya (Tsukuba,JP), A Sato (Tsukuba,JP), T Hoshi (Tsukuba,JP), T Ichinohe (Tsukuba,JP), S Sakai (Tsukuba,JP), H Watabe (Tsukuba,JP), M Ieda (Tsukuba,JP)

Authors:
D Hiraya1 , A Sato1 , T Hoshi1 , T Ichinohe1 , S Sakai1 , H Watabe1 , M Ieda1 , 1Cardiovascular Division, Faculty of Medicine, University of Tsukuba - Tsukuba - Japan ,

Citation:

Objectives: This study aimed to evaluate the association with coronary high-intensity plaque (HIP) on non-contrast T1-weighted magnetic resonance imaging (T1WI) and circulating levels of malondialdehyde-modified low-density lipoprotein (MDA-LDL). 
Methods: A total of 139 patients with coronary artery stenosis (>70%) were imaged with non-contrast T1WI by using a 1.5-T magnetic resonance system (HIP: n=60, non-HIP: n=79). HIP was defined as a signal intensity of coronary plaque to cardiac muscle ratio (PMR) of =1.4. At admission, circulating levels of MDA-LDL and other lipid-related markers (triglyceride, HDL, LDL, Lp(a), RLP-C, and EPA/AA) were measured. 
Results: Circulating levels of MDA-LDL (p=0.001) and LDL (p=0.041) were significantly higher in patients with HIP than those without, whereas the other lipid-related markers were not significantly different between both groups. In multivariable logistic regression analysis, MDA-LDL levels were independently associated with the presence of HIP (OR 1.03; 95% CI, 1.00-1.06, p=0.015) after adjusting for cofounding factors (age, sex, triglyceride, LDL, Lp(a), RLP-C, and EPA/AA). The optimal MDA-LDL threshold for predicting coronary HIP was 90.4 U/L, identified by the receiver operating characteristic curve.
Conclusion: MDA-LDL levels might be associated with the presence of HIP in patients with coronary artery disease.

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