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Hypertension or diabetes; which is worse prognostic factor for acute coronary syndrome patients following percutaneous coronary intervention?
Sub-topic : Coronary Artery Disease and Comorbidities
Session type : Poster Session
Authors : YH Kim (Chuncheon City,KR), AY Her (Chuncheon City,KR), SW Rha (Seoul,KP), BG Choi (Seoul,KP), SY Choi (Seoul,KP), JK Byun (Seoul,KP), CU Choi (Seoul,KP), EJ Kim (Seoul,KP), CG Park (Seoul,KP), HS Seo (Seoul,KP), DJ Oh (Seoul,KP)
Background: Hypertension and diabetes are well known risk factors of ischemic coronary artery disease (CAD). However, head-to-head comparison results regarding their impact on long-term (10-year) clinical outcomes in acute coronary syndrome (ACS) patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) are rare.
Methods: From April 2003 to May 2015, a total of 2056 ACS patients who had hypertension or diabetes were enrolled. The patients who had both hypertension and diabetes were excluded. Finally, a total of 1344 eligible ACS patients who had hypertension (n=1,108) or diabetes (n=236) were enrolled. To adjust for any potential confounders, a propensity score matched (PSM) analysis was performed using the logistic regression model and 2 propensity-matched groups (236 pairs, n=472, C-statistic = 0.785) were generated. Cumulative major adverse cardiac events (MACEs) up to 10-year were compared between the hypertension group and diabetes group. MACEs was defined as total death, non-fatal myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR), and non-target vessel revascularization (Non-TVR).
Results: Up to 10-year follow-up periods, the cumulative incidence of total death, non-fatal MI, TLR, TVR and non-TVR were not significantly different between the hypertension group and diabetes group. Further, the cumulative incidence of MACEs were also similar between the two groups (Table).
Conclusions: Up to 10-year follow-up periods, hypertension and diabetes seem to be similarly important prognostic risk factors for ACS patients.
Table 1. Cumulative clinical outcomes up to 10-year between hypertension group and diabetes group
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