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Free fatty acids is a useful marker for predicting clinical outcomes in patients with stable coronary artery disease

Session Poster session 1

Speaker Huiwen Zhang

Event : ESC Congress 2017

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Coronary Artery Disease (Chronic)
  • Session type : Poster Session

Authors : HW Zhang (Beijing,CN), X Zhao (Beijing,CN), YL Guo (Beijing,CN), NQ Wu (Beijing,CN), CG Zhu (Beijing,CN), Y Zhang (Beijing,CN), S Li (Beijing,CN), Y Gao (Beijing,CN), P Qing (Beijing,CN), XL Li (Beijing,CN), G Liu (Beijing,CN), Q Dong (Beijing,CN), JJ Li (Beijing,CN)

H.W. Zhang1 , X. Zhao1 , Y.L. Guo1 , N.Q. Wu1 , C.G. Zhu1 , Y. Zhang1 , S. Li1 , Y. Gao1 , P. Qing1 , X.L. Li1 , G. Liu1 , Q. Dong1 , J.J. Li1 , 1Fu Wai Hospital, Division of Dyslipidemia - Beijing - China People's Republic of ,

European Heart Journal ( 2017 ) 38 ( Supplement ), 203

Background: Previous studies have revealed that elevation of plasma free fatty acids (FFAs) is related tocardiovascular disease. However, the role of FFAs in predicting clinical outcomes of stable coronary artery disease (SCAD) has less been evaluated.

Purpose: The objective of this study, therefore, was to investigate the prognostic value of FFAs in Chinese cohort with angiography-proven SCAD.

Methods: We have measured the baseline plasmaconcentrations of FFAs in 1670 consecutive patients with angina-like chest pain who underwent coronary angiographyand were followed up for an average time of 36.9 months. According to the quartiles of baseline FFAs, the patientswere divided into four groups. The baseline characteristics and laboratory parameters were collected. The relationshipof baseline FFAs levels and cardiovascular events (CVEs) including all-cause mortality, non-fatal myocardial infarction, ischemic stroke and coronary revascularization were evaluated.

Results: During the follow-up period, 146patientssuffered from CVEs. Using the Cox proportional hazards model, the unadjusted hazard ratio (HR) for CVEs in the fourth FFA quartile was 2.092 (95% CI: 1.315–3.328; P=0.002) when compared with that in the first FFA quartile. After adjustment for traditional cardiovascular risk factors, the HR in the fourth versus first quartile remained significantat1.764 (95% CI: 1.084–2.870; P=0.022).

Conclusions: The present study on Chinese cohort with angiography-proven SCAD suggested that increased plasma level of FFAs was an independent risk factor of predicting for CVEs.

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