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Differential platelet alpha2B-adrenergic receptors gene expression levels following coronary stent implantation: the effect of Bioabsorbable Polymer Everolimus-Eluting Synergy stents

Session Poster session 1

Speaker Maria Marketou

Event : ESC Congress 2017

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Coronary Artery Disease (Chronic)
  • Session type : Poster Session

Authors : M Marketou (Heraklion,GR), A Spanaki (Heraklion,GR), F Parthenakis (Heraklion,GR), J Kontaraki (Heraklion,GR), E Zacharis (Heraklion,GR), D Lempidakis (Heraklion,GR), G Mpantouvakis (Heraklion,GR), J Konstantinou (Heraklion,GR), J Logakis (Heraklion,GR), D Vougia (Heraklion,GR), O Theodosaki (Heraklion,GR), M Vernardos (Heraklion,GR), P Vardas (Heraklion,GR)

Authors:
M. Marketou1 , A. Spanaki1 , F. Parthenakis1 , J. Kontaraki1 , E. Zacharis1 , D. Lempidakis1 , G. Mpantouvakis1 , J. Konstantinou1 , J. Logakis1 , D. Vougia1 , O. Theodosaki1 , M. Vernardos1 , P. Vardas1 , 1Heraklion University Hospital - Heraklion - Greece ,

Citation:
European Heart Journal ( 2017 ) 38 ( Supplement ), 185

Purpose: Alpha2B-adrenergic receptors (α2B-ARs) play a pivotal role in platelet aggregation and their blockade exerts a profound antiaggregatory effect. In this report, we evaluated alpha2B–adrenergic receptors (α2B–ARs) gene expression levels in platelets from patients with stable coronary artery disease (CAD) undergoing coronary stent implantation.

Methods: Fifty nine patients with stable CAD (39 males, aged 68±16 years) who were under dual antiplatelet therapy with clopidogrel 75 mg and acetylsalicylic acid 100 mg and 20 healthy individuals (37 males, aged 69±8 years) were included. The patients underwent single vessel elective percutaneous coronary intervention and were randomized to one of three groups, for bare metal stents (BMS) or everolimus-eluting stents (EES) (n=19) or Bioabsorbable Polymer Everolimus-Eluting Synergy stents (Boston Scientific) implantation (n=22). Blood samples were obtained before, 24hours, 48 hours, and 1 month after stent implantation from which platelets were isolated. The α2B-ARs gene expression in platelets was examined by real time PCR.

Results: Patients with BMS showed a significantly increased gene expression of the α2B-ARs in platelets in 1 month following stent implantation (p=0.04) while EES group revealed an increase at 48 hours (p=0.05) and returned to baseline values in 1 month (Table 1). In contrast, α2B-ARs gene expression levels in Synergy group were significantly decreased at 1 month follow up (p=0.045).

Conclusions: In contrast to other types of stents, Synergy stents showed a decrease in platelets α2B-ARs gene expression levels after implantation. Possibly, this type of stent offers a favorable effect in the prevention of stent thrombosis in CAD patients.

Table 1. Serial changes of platelets α2B-ARs gene expression levels after stent implantation
Baseline24 hours48 hours1 month
BMS (n=18)3.01±3.855.41±9.025.86±7.737.18±7.78*
EES (n=19)3.65±3.565.66±5.411.15±15*5.4±6.33
Synergy stents (n=22).4.06±4.863.53±3.583.06±2.452.083±1.58*
*p<0.005 compared to baseline.

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