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Supervised exercise training in patients with peripheral arterial disease is associated with an increase of vascular stress and profunda femoral artery diameter

Session Poster session 2

Speaker Joern Fredrik Dopheide

Event : ESC Congress 2016

  • Topic : preventive cardiology
  • Sub-topic : Exercise Testing
  • Session type : Poster Session

Authors : J F Dopheide (Mainz,DE), J Rubrech (Mainz,DE), A Trumpp (Mainz,DE), P Geissler (Mainz,DE), G Zeller (Mainz,DE), B Schnorbus (Mainz,DE), F P Schmidt (Mainz,DE), T Gori (Mainz,DE), T Munzel (Mainz,DE), C Espinola-Klein (Mainz,DE)

Authors:
J.F. Dopheide1 , J. Rubrech1 , A. Trumpp1 , P. Geissler1 , G. Zeller1 , B. Schnorbus1 , F.P. Schmidt1 , T. Gori1 , T. Munzel1 , C. Espinola-Klein1 , 1University Hospital of Mainz - Mainz - Germany ,

Citation:
European Heart Journal ( 2016 ) 37 ( Abstract Supplement ), 332

Background: Arteriogenesis is promoted by flow and pressure related forces like tangential wall stress and fluid shear stress.Exercise training (ET) is known to promote arteriogenesis in peripheral arterial disease (PAD) patients. It remains unclear whether supervised ET (SET) promotes arteriogenesis more efficiently than non-supervised ET (nSET).

Methods and results: 40 PAD patients participated in a SET or nSET training program (n=20 each) and compared to 20 healthy individuals without any history of cardiovascular events. Femoral artery diameter, flow and velocity were measured by ultrasound. Tangential wall stress and fluid shear stress were calculated for femoral arteries. Follow up was performed after a mean of 7.65±1.62 months. At follow up only the SET group showed a significant increase in lumen diameter of profunda femoral artery (p=0.03), accompanied by an increase of tangential wall stress (p=0.002). Fluid shear stress decreased but remained higher for SET compared to controls (p<0.01). Individual changes in walking distance were higher for SET patients (p=0.01) than nSET patients (p=0.07). Profunda femoral lumen diameter and tangential wall stress correlated directly with walking distance (r = 0.446; p<0.001), as well as with each other (r = 0.743; p<0.0001).

Conclusions: Our results indicate SET to promote arteriogenesis more efficiently than nSET. Femoral lumen diameter and flow might help monitoring exercise training efficiency and potential arteriogenesis.

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