In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.

Member Benefit

This content is only available year-round to ESC Professional Members, Fellows of the ESC, and Young Combined Members

Pulmonary artery denervation for improving outcome in patients with residual pulmonary hypertension after pulmonary thromboendarterectomy.: early experience

Session Best Posters session 4

Speaker Natalya Novikova

Event : ESC Congress 2016

  • Topic : valvular, myocardial, pericardial, pulmonary, congenital heart disease
  • Sub-topic : Pulmonary Hypertension
  • Session type : Best ePosters

Authors : N Novikova (Novosibirsk,RU), A Cherniavskiy (Novosibirsk,RU), E Pokushalov (Novosibirsk,RU), A Edemskiy (Novosibirsk,RU), A Romanov (Novosibirsk,RU)

Authors:
N. Novikova1 , A. Cherniavskiy1 , E. Pokushalov1 , A. Edemskiy1 , A. Romanov1 , 1State Research Institute of Circulation Pathology - Novosibirsk - Russian Federation ,

Topic(s):
Chronic pulmonary hypertension

Citation:
European Heart Journal ( 2016 ) 37 ( Abstract Supplement ), 646

Aim: To evaluate safety and efficacy of pulmonary artery radiofrequency denervation (PADN) for pulmonary artery (PA) pressure decrease in patients with residual pulmonary hypertension after pulmonary thromboendarterectomy.

Methods: PADN was performed in 14 patients with residual pulmonary hypertension after pulmonary thromboendarterectomy. Indication for PADN was mean PA pressure level >25 mm Hg with absence of proximal PA lesion according to CT scan. For PADN efficacy assessment with V/Q-scanning, echocardiography, right heart catheterization and 6-minute walking distance test were performed. During preoperative evaluation subsegmental PA perfusion defects were revealed in all patients. PADN was performed using of nonfluoroscopic 3-D navigation system with standard catheter for radiofrequency ablation. Swan-Ganz catheter was used for intraoperative hemodynamic measurements. All patients were followed up during 30 days after procedure.

Results: There were no complications or death during the procedure and before discharge. Mean procedure time was 105 [93; 120] min. After PADN the mean PA pressure decrease from 37,3 mm Hg [29; 38] to 24,6 [17; 30] mm Hg (p=0,011) and pulmonary vascular resistance from 672 [387; 566] dyn sec cm–5 to 386 [155; 449] dyn sec cm–5 (p=0.017). There were no significant increase of cardiac output and 6-minute walking distance test compared to baseline data (3,4 [3,2; 3,4] l/min vs 3,5 [3,2; 4,0] l/min; p=0,4012 and 427 meters [352; 510] vs 447 m [370; 525]; p=0.1614, respectively). All patients noticed reduction of dyspnea and improving exercise tolerance.

Conclusion: Our initial experience demonstrated that PADN in patients with residual pulmonary hypertension after pulmonary thromboendarterctomy is safe and effective it terms of pulmonary PA decrease. Long-term follow up and further studies are needed to assess the role of PADN in the treatment of these category of patients.

Member Benefit

This content is only available year-round to ESC Professional Members, Fellows of the ESC, and Young Combined Members

Get your access to resources

Join now
  • 1ESC Professional Members – access all ESC Congress resources 
  • 2ESC Association Members (Ivory, Silver, Gold) – access your Association’s resources
  • 3Under 40 or in training - with a Combined Membership, access all resources
Join now
logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are