In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.

The free consultation period for this content is over.

It is now only available year-round to ESC Professional Members, Fellows of the ESC, and Young combined Members

Plasma chemerin is elevated in type 2 diabetes, is associated with impaired kidney function and is predictive for cardiovascular events

Session Poster session 7

Speaker Christoph Saely

Event : ESC Congress 2015

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Coronary Artery Disease – Pathophysiology and Mechanisms
  • Session type : Poster Session

Authors : A Leiherer (Feldkirch,AT), A Muendlein (Feldkirch,AT), P Rein (Feldkirch,AT), K Geiger (Feldkirch,AT), P Fraunberger (Feldkirch,AT), H Drexel (Philadelphia,US), CH Saely (Feldkirch,AT)

A. Leiherer1 , A. Muendlein1 , P. Rein2 , K. Geiger1 , P. Fraunberger3 , H. Drexel4 , C.H. Saely2 , 1VIVIT Institute - Feldkirch - Austria , 2Academic Teaching Hospital, Department of Medicine and Cardiology - Feldkirch - Austria , 3Academic Teaching Hospital, Medical Central Laboratory - Feldkirch - Austria , 4Drexel University College of Medicine - Philadelphia - United States of America ,

European Heart Journal ( 2015 ) 36 ( Abstract Supplement ), 1096

Background and introduction: Chemerin has been implicated in autocrine/paracrine signaling for adipocyte differentiation and also stimulation of lipolysis. Whether chemerin is predictive for cardiovascular events is still unclear.

Purpose: The purpose of our study was to investigate the association of chemerin with cardiovascular event risk.

Methods: We measured plasma chemerin levels in 495 patients undergoing coronary angiography for the evaluation of established or suspected stable CAD.

Results: Chemerin was higher in patients with type 2 diabetes mellitus (T2DM, n=111) than in non-diabetic subjects (192±73 vs. 170±65 ng/ml, p=0.001). Further, chemerin was significantly and independently associated with the glomerular filtration rate (GFR) in analysis of covariance using age, sex, and BMI as covariates (F=49.6, p<0.001). Prospectively, we recorded 107 cardiovascular events over 3.5 years. Chemerin both univariately and after multivariate adjustment including baseline GFR significantly predicted cardiovascular events, with hazard ratios of 1.83 [95% CI 1.19–2.83], p=0.006 and 1.67 [1.05–2.67], p=0.030 for the top tertile of chemerin versus the first and second tertiles, respectively. A cardiometabo-chip-analysis revealed an association of two nearby located SNPs in TP53BP1 and CAPN3 rs2444030 nominal p-value=5.2 e-9, and rs3098423 nominal p-value=9.6 e-8) with chemerin concentration. Haplotype analysis for these two SNPs revealed a significantly impaired GFR associated with the fully mutated haplotype compared to all other haplotypes (OR=0.63, p=0.006).

Conclusion: We conclude that high chemerin is characteristic of T2DM, is associated with impaired kidney function, and is predictive for cardiovascular events.

Members get more

Join now
  • 1ESC Professional Members – access all resources from general ESC events 
  • 2ESC Association Members (Ivory, Silver, Gold) – access your Association’s resources
  • 3Under 40 or in training - with a Combined Membership, access all resources
Join now

Our sponsors

ESC 365 is supported by Bayer, Boehringer Ingelheim and Lilly Alliance, Bristol-Myers Squibb and Pfizer Alliance, Novartis Pharma AG and Vifor Pharma in the form of educational grants. The sponsors were not involved in the development of this platform and had no influence on its content.

logo esc

Our mission: To reduce the burden of cardiovascular disease

Who we are