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Plasma chemerin is elevated in type 2 diabetes, is associated with impaired kidney function and is predictive for cardiovascular events

Session Poster session 7

Speaker Christoph Saely

Event : ESC Congress 2015

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Coronary Artery Disease – Pathophysiology and Mechanisms
  • Session type : Poster Session

Authors : A Leiherer (Feldkirch,AT), A Muendlein (Feldkirch,AT), P Rein (Feldkirch,AT), K Geiger (Feldkirch,AT), P Fraunberger (Feldkirch,AT), H Drexel (Philadelphia,US), CH Saely (Feldkirch,AT)

Authors:
A. Leiherer1 , A. Muendlein1 , P. Rein2 , K. Geiger1 , P. Fraunberger3 , H. Drexel4 , C.H. Saely2 , 1VIVIT Institute - Feldkirch - Austria , 2Academic Teaching Hospital, Department of Medicine and Cardiology - Feldkirch - Austria , 3Academic Teaching Hospital, Medical Central Laboratory - Feldkirch - Austria , 4Drexel University College of Medicine - Philadelphia - United States of America ,

Citation:
European Heart Journal ( 2015 ) 36 ( Abstract Supplement ), 1096

Background and introduction: Chemerin has been implicated in autocrine/paracrine signaling for adipocyte differentiation and also stimulation of lipolysis. Whether chemerin is predictive for cardiovascular events is still unclear.

Purpose: The purpose of our study was to investigate the association of chemerin with cardiovascular event risk.

Methods: We measured plasma chemerin levels in 495 patients undergoing coronary angiography for the evaluation of established or suspected stable CAD.

Results: Chemerin was higher in patients with type 2 diabetes mellitus (T2DM, n=111) than in non-diabetic subjects (192±73 vs. 170±65 ng/ml, p=0.001). Further, chemerin was significantly and independently associated with the glomerular filtration rate (GFR) in analysis of covariance using age, sex, and BMI as covariates (F=49.6, p<0.001). Prospectively, we recorded 107 cardiovascular events over 3.5 years. Chemerin both univariately and after multivariate adjustment including baseline GFR significantly predicted cardiovascular events, with hazard ratios of 1.83 [95% CI 1.19–2.83], p=0.006 and 1.67 [1.05–2.67], p=0.030 for the top tertile of chemerin versus the first and second tertiles, respectively. A cardiometabo-chip-analysis revealed an association of two nearby located SNPs in TP53BP1 and CAPN3 rs2444030 nominal p-value=5.2 e-9, and rs3098423 nominal p-value=9.6 e-8) with chemerin concentration. Haplotype analysis for these two SNPs revealed a significantly impaired GFR associated with the fully mutated haplotype compared to all other haplotypes (OR=0.63, p=0.006).

Conclusion: We conclude that high chemerin is characteristic of T2DM, is associated with impaired kidney function, and is predictive for cardiovascular events.

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