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Monocyte subset distribution in patients with stable atherosclerosis and elevated levels of lipoprotein(a)

Session Poster session 7

Speaker Konstantin A Krychtiuk

Event : ESC Congress 2015

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Coronary Artery Disease – Pathophysiology and Mechanisms
  • Session type : Poster Session

Authors : KA Krychtiuk (Vienna,AT), SP Kastl (Vienna,AT), SL Hofbauer (Vienna,AT), A Wonnerth (Vienna,AT), G Maurer (Vienna,AT), K Huber (Vienna,AT), E Dostal (Vienna,AT), S Oravec (Bratislava,SK), J Wojta (Vienna,AT), WS Speidl (Vienna,AT)

K.A. Krychtiuk1 , S.P. Kastl1 , S.L. Hofbauer1 , A. Wonnerth1 , G. Maurer1 , K. Huber2 , E. Dostal3 , S. Oravec4 , J. Wojta1 , W.S. Speidl1 , 1Medical University of Vienna, Department of Internal Medicine II, Division of Cardiology - Vienna - Austria , 2Wilhelminen Hospital, 3rd Department of Internal Medicine, Cardiology and Emergency Medicine - Vienna - Austria , 3Krankenanstalten Dr. Dostal - Vienna - Austria , 4Comenius University - Bratislava - Slovak Republic ,

European Heart Journal ( 2015 ) 36 ( Abstract Supplement ), 1095

Purpose: Lipoprotein(a) is a pro-atherogenic plasma lipoprotein currently established as an independent risk factor for the development of atherosclerotic disease and as a predictor for acute thrombotic complications. Today, atherosclerosis is considered to be an inflammatory disease of the vessel wall in which monocytes and monocyte-derived macrophages are crucially involved. Circulating monocytes can be divided according to their surface expression pattern of CD14 and CD16 into at least three subsets with distinct inflammatory and atherogenic potential. Therefore, the aim of this study was to examine whether elevated levels of Lp(a) are associated with changes in monocyte subset distribution.

Methods: We included 90 patients with stable coronary artery disease (CAD). Lp(a) was measured and monocyte subsets were identified as classical monocytes (CD14++CD16-; CM), intermediate monocytes (CD14++CD16+; IM) and non-classical monocytes (CD14+CD16++; NCM) by flow cytometry.

Results: In patients with elevated levels of Lp(a) (>50mg/dL), monocyte subset distribution was skewed towards an increase in the proportion of IM (7.0±3.8% vs. 5.2±3.0%; p=0.026), while CM (82.6±6.5% vs. 82.0±6.8%; p=0.73) and NCM (10.5±5.3 vs. 12.8±6.0; p=0.10) remained unchanged. This association was independent of clinical risk factors, choice of statin treatment regime and inflammatory markers.

Conclusion: In conclusion, we provide a new link between elevated levels of Lp(a) and a proatherogenic distribution of monocyte subtypes in patients with stable atherosclerotic disease.

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