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Increased consumption of fat and carbohydrates is associated with severe coronary artery disease

Session Poster session 7

Speaker Evangelos Oikonomou

Event : ESC Congress 2015

  • Topic : preventive cardiology
  • Sub-topic : Nutrition, Malnutrition and Heart Disease
  • Session type : Poster Session

Authors : G Siasos (Athens,GR), E Kokkou (Athens,GR), E Georgousopoulou (Athens,GR), E Oikonomou (Athens,GR), T Psaltopoulou (Athens,GR), K Mourouzis (Athens,GR), M Zaromytidou (Athens,GR), S Tsalamandris (Athens,GR), E Dimitropoulos (Athens,GR), D Tousoulis (Athens,GR)

G. Siasos1 , E. Kokkou1 , E. Georgousopoulou1 , E. Oikonomou1 , T. Psaltopoulou2 , K. Mourouzis1 , M. Zaromytidou1 , S. Tsalamandris1 , E. Dimitropoulos1 , D. Tousoulis1 , 1University of Athens Medical School, 1st Cardiology Department, “Hippokration” Hospital - Athens - Greece , 2University of Athens Medical School, Department of Hygiene, Epidemiology and Medical Statistics - Athens - Greece ,

European Heart Journal ( 2015 ) 36 ( Abstract Supplement ), 1154

Background: The association of dietary pattern with cardiovascular disease is well established.

Purpose: To examine the association between different dietary patterns and the severity of coronary artery disease (CAD).

Methods: The study population consisted of 188 consecutive symptomatic CAD patients recruited from the outpatient cardiology department of our Hospital. All patients underwent coronary angiography and they were categorized in subjects with one, two or three vessel disease (1VD, 2VD, 3VD respectively) and in subjects with left main (LM) disease. Patients with LM disease (stenosis≥50%), 3VD, or 2VD marked by stenosis of the proximal left anterior descending artery ≥70% were characterized as having angiographically severe CAD. Among several other demographics and clinical characteristics all subjects were tested with a validated semi quantitative food frequency questionnaire. Univariate and multivariate (principal components analysis) analyses were used in order to evaluate the relationship between dietary habits and the severity of CAD, adjusting for potential confounders.

Results: After adjusting for all traditional risk factors (diabetes mellitus, hypertension, hyperlipidemia, family history of CAD and smoking habits), an increase in red meat consumption lead to a 47% increase in the probability of having severe CAD (p<0.01). Body mass index did not differ between patients with severe and non-severe CAD (p=0.11). Moreover, dietary pattern consisting of high consumption of red meat, sweets, pasta, potatoes and low consumption of fruits and vegetables (western type diet) was associated with higher probability of having severe CAD (p<0.01). This association between “Western type” diet and severe CAD was also evident even after adjustment for several cardiovascular risk factors (OR=1.9, p=0.022).

Conclusion: Dietary patterns affect the progression and severity of CAD. Western type diet is associated with the extent of CAD independently from traditional cardiovascular risk factors. Further studies are needed to elucidate the impact of different dietary patterns on cardiovascular health.

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