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Impaired endothelial function and arterial stiffness in patients with pseudoexfoliative glaucoma

Session Poster session 2

Speaker Evangelos Oikonomou

Event : ESC Congress 2015

  • Topic : basic science
  • Sub-topic : Basic Science - Vascular Biology and Physiology
  • Session type : Poster Session

Authors : G Siasou (Athens,GR), G Siasos (Athens,GR), M Moschos (Athens,GR), N Gouliopoulos (Athens,GR), E Oikonomou (Athens,GR), T Paraskevopoulos (Athens,GR), M Zaromytidou (Athens,GR), K Mourouzis (Athens,GR), S Tsalamandris (Athens,GR), D Tousoulis (Athens,GR)

G. Siasou1 , G. Siasos1 , M. Moschos2 , N. Gouliopoulos1 , E. Oikonomou1 , T. Paraskevopoulos2 , M. Zaromytidou1 , K. Mourouzis1 , S. Tsalamandris1 , D. Tousoulis1 , 1University of Athens Medical School, 1st Cardiology Department, “Hippokration” Hospital - Athens - Greece , 2University of Athens Medical School, Division of Opthalmology - Athens - Greece ,

European Heart Journal ( 2015 ) 36 ( Abstract Supplement ), 259

Background: Primary open-angle glaucoma (POAG) is one of the most prevalent causes of irreversible blindness and is associated with endothelial dysfunction and arterial stiffness. Pseudoexfoliative glaucoma (PEG) is another type of glaucoma observed in pseudoexfoliation syndrome. It is characterized by the deposition of pseudoexfoliative material not only to the anterior segment of the eye, but also to the vessels, heart and other organs.

Purpose: We evaluated the association of endothelial function and arterial stiffness with POAG and PEG

Methods: Forty four POAG patients, 22 PEG and 38 healthy subjects (Cl) were included in this study. All subjects were free of cardiovascular or inflammatory diseases. Endothelial function was evaluated by flow-mediated dilatation (FMD). Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) as a measure of arterial wave reflections

Results: Between the three study groups CL, POAG, PEG there was no difference in age (67±10 years vs. 70±9 years vs. 66±12yeras, p=0.12) or prevalence of male sex (70% vs. 57% vs. 50%, p=0.21). Importantly, there was a linear impairment of FMD (7.35±2.77% vs. 6.58±3.18% vs. 4.88±3.29%, p=0.006), PWV (7.98±1.56m/sec vs. 9.20±1.84m/sec vs. 9.22±2.16m/sec, p=0.004) and AIx (21.29±8.77% vs. 25.14±5.71% vs. 28.20±8.75%, p=0.002) from CL to POAG and PEG. Interestingly post hoc test after Scheffe correction revealed also that PEG subjects had not only significantly impaired FMD, compared to control subjects, but also compared to POAG subjects (4.88±3.29% vs. 6.58±3.18%, p=0.02).

Conclusion: Endothelial function and arterial stiffness is significantly impaired in patients with pseudoexfoliative glaucoma. These findings shed some light in the pathophysiology of pseudoexfoliative glaucoma and support the theory that pseudoexfoliative fibrils may also accumulate and damage the arterial wall.

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