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Remnant cholesterol predicts cardiovascular event risk in patients with type 2 diabetes independently from the baseline coronary artery disease state

Session Poster session 2

Speaker Christoph Saely

Event : ESC Congress 2015

  • Topic : preventive cardiology
  • Sub-topic : Lipids
  • Session type : Poster Session

Authors : CH Saely (Feldkirch,AT), D Zanolin (Triesen,LI), P Rein (Feldkirch,AT), A Vonbank (Feldkirch,AT), A Leiherer (Feldkirch,AT), A Muendlein (Feldkirch,AT), H Drexel (Philadelphia,US)

Authors:
C.H. Saely1 , D. Zanolin2 , P. Rein1 , A. Vonbank1 , A. Leiherer3 , A. Muendlein3 , H. Drexel4 , 1Academic Teaching Hospital, Department of Medicine and Cardiology - Feldkirch - Austria , 2Private University of the Principality of Liechtenstein - Triesen - Liechtenstein , 3VIVIT Institute - Feldkirch - Austria , 4Drexel University College of Medicine - Philadelphia - United States of America ,

Citation:
European Heart Journal ( 2015 ) 36 ( Abstract Supplement ), 292

Background and introduction: Remnant cholesterol, which is calculated as total cholesterol minus LDL cholesterol minus HDL cholesterol recently has attracted interest as a marker of cardiovascular event risk.

Purpose: Whether remnant cholesterol has the power to predict cardiovascular events in patients with type 2 diabetes (T2DM) as well as in non-diabetic patients in whom the baseline coronary artery disease (CAD) state was verified angiographically is still unclear and was therefore adressed in this study.

Methods: We enrolled 1774 consecutive patients undergoing coronary angiography for the evaluation of established or suspected stable CAD. Prospectively, cardiovascular events were recorded over a mean follow-up period of 7.5±2.9 years. Diabetes was diagnosed according to ADA criteria.

Results: During follow-up, 32.5% of our patients suffered cardiovascular events; the event rate was significantly higher in patients with T2DM (n=513) than in nodiabetic subjects (40.5 vs. 29.3%; p<0.001). Remnant cholesterol significantly predicted cardiovascular events in the total study population, among patients with T2DM, as well as among non-diabetic subjects both univariately (HR 1.18 [1.10–1.27], p<0.001, 1.20 [1.05–1.38], p=0.008 and 1.19 [1.09–1.30], p<0.001, respectively) and after multivariate adjustment including presence as well as extent of baseline CAD (HR 1.15 [1.07–1.24], p<0.001, 1.21 [1.05–1.39], p=0.009 and 1.15 [1.05–1.25], p=0.002, respectively).

Conclusion: From our data we conclude that remnant cholesterol predicts cardiovascular event risk in patients with type 2 diabetes as well as in non-diabetic patients independently from the baseline CAD state.

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