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Leptin serum levels are independently determined by obesity and by the presence of the metabolic syndrome

Session Poster session 7

Speaker Christoph Saely

Event : ESC Congress 2014

  • Topic : preventive cardiology
  • Sub-topic : Obesity
  • Session type : Poster Session

Authors : D Zanolin (Feldkirch,AT), CH Saely (Triesen,LI), A Vonbank (Fedlkirch,AT), P Rein (Fedlkirch,AT), H Drexel (Philadelphia,US)

D. Zanolin1 , C.H. Saely2 , A. Vonbank3 , P. Rein3 , H. Drexel4 , 1VIVIT Institute - Feldkirch - Austria , 2Private University of the Principality of Liechtenstein - Triesen - Liechtenstein , 3Academic Teaching Hospital, Department of Internal Medicine - Fedlkirch - Austria , 4Drexel University College of Medicine - Philadelphia - United States of America ,

European Heart Journal ( 2014 ) 35 ( Abstract Supplement ), 1074

Purpose: Obesity is a major risk factor for the metabolic syndrome (MetS), but some obese individuals do not have the MetS while others have the MetS but are non-obese. The single and joint associations of the adipokine leptin with obesity and the MetS have not yet been investigated and are addressed in the present study.

Methods: We measured leptin in four groups of patients: subjects who were non-obese and did not have the MetS (n=196), non-obese patients with the MetS (n=149), obese subjects who did not have the MetS (n=13) and obese patients with the MetS (n=77). Obesity was defined as a BMI ≥30kg/m2; presence of the MetS was defined according to the current harmonized consensus definition.

Results: Compared to serum leptin in non-obese subjects who did not have the MetS (6.71±7.83 ng/ ml), leptin was significantly higher in non-obese subjects with the MetS (9.29±7.53 ng/ml; p<0.001), as well as in obese subjects without (11.15±9.75 ng/ml; p=0.016) or obese patients with the MetS (15.92±11.61 ng/ml; p<0.001), in whom leptin trendend (p=0.127) to be higher than in obese patients without the MetS and was significantly (p<0.001) higher than in non-obese patients with the MetS. Analysis of covariance showed that both obesity and the MetS significantly and independently predicted serum leptin, with obesity being the stronger predictor (F=17.016; p<0.001) than presence of the MetS (F=7.60; p=0.006).

Conclusions: Obesity and presence of the MetS are independent determinants of serum leptin, but obesity explains a larger amount of serum leptin variation than the presence of the MetS.

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