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Aortic stiffness in the presence of self-limiting and sustained systemic inflammation: comparison of acute myocarditis and chronic inflammatory diseases

Session Poster session 5

Speaker Rocio Hinojar Baydes

Congress : ESC Congress 2014

  • Topic : imaging
  • Sub-topic : Cardiac Magnetic Resonance
  • Session type : Poster Session
  • FP Number : P4459

Authors : R Hinojar (London,GB), E Arroyo Ucar (London,GB), N Binti Ngah (London,GB), N Kuo (London,GB), D D Cruz (London,GB), N Gaddum (London,GB), T Schaeffter (London,GB), E Nagel (London,GB), VO Puntmann (London,GB)

R. Hinojar1 , E. Arroyo Ucar1 , N. Binti Ngah1 , N. Kuo1 , D. D Cruz1 , N. Gaddum1 , T. Schaeffter1 , E. Nagel1 , V.O. Puntmann1 , 1King's College London, Cardiovascular Division, St. Thomas' Hospital - London - United Kingdom ,

European Heart Journal ( 2014 ) 35 ( Abstract Supplement ), 792-793

Purpose: Aortic stiffness, measured by pulse way velocity (PWV), is an independent predictor of cardiovascular (CV) events over and above traditional risk factors. Previous evidence revealed moderately raised PWV in the presence of presence of systemic inflammatory diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Changes in aortic stiffness in response to acute systemic inflammation, such as systemic viral myocarditis, remain unknown.

Methods: Ninety-nine subjects with either clinical diagnosis of acute myocarditis (n=44) or chronic systemic inflammatory disease (RA and SLE, n=55) underwent standardized cardiac magnetic resonance protocol for the assessment of PWV. Thirty-eight apparently healthy subjects served as control group. Central PWV was obtained by an inplane phase contrast gradient echo sequence with high temporal resolution (120 phases/cardiac cycle) and foot-to-foot measurement.

Results: Groups were well matched for age and cardiovascular risk factors, with no differences in blood pressure or heart rate between groups. Compared to controls, both patients' groups had significantly raised central PWV (control vs. acute myocarditis vs. systemic inflammation, PWV (m/sec): 5.1±1.0 vs. 8.4±2.4 vs. 8.5±2.6, p<0.001, with no significant differences between the two groups of patients on post-hoc analysis. We identified significant relationship between PWV and age (controls, r: 0.56; acute myocarditis, r: 0.51; and systemic inflammation, r: 0.3 p<0.0001 for all), whereas no other functional index showed significant association.

Conclusion: We demonstrate for the first time that there is increased aortic stiffness in response to self-limiting inflammatory injury, which is comparable in magnitude to sustained systemic inflammation.

PWV bivariate correlations
PWVrSign (p value)
PWV was significantly correlated with age, with traditional CV risk factors and with the presence of areas of late gadolinium enhancement (LGE) in the CMR study.

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