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Body mass index significantly modulates the power of C-reactive protein to predict cardiovascular event risk among angiographied coronary patients

Session Poster session 4

Speaker Christoph Saely

Event : ESC Congress 2014

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Acute Coronary Syndromes: Biomarkers
  • Session type : Poster Session

Authors : A Vonbank (Fedlkirch,AT), CH Saely (Triesen,LI), D Zanolin (Feldkirch,AT), P Rein (Fedlkirch,AT), A Said (Feldkirch,AT), H Drexel (Philadelphia,US)

A. Vonbank1 , C.H. Saely2 , D. Zanolin3 , P. Rein1 , A. Said3 , H. Drexel4 , 1Academic Teaching Hospital, Department of Internal Medicine - Fedlkirch - Austria , 2Private University of the Principality of Liechtenstein - Triesen - Liechtenstein , 3VIVIT Institute - Feldkirch - Austria , 4Drexel University College of Medicine - Philadelphia - United States of America ,

European Heart Journal ( 2014 ) 35 ( Abstract Supplement ), 569

Purpose: Epidemiological studies in various populations show that obesity is associated with inflammation and with increased cardiovascular risk, and that the inflammatory marker C-reactive protein (CRP) strongly predicts the incidence of cardiovascular events. Whether CRP is equally predictive of cardiovascular event risk in obese patients and in non-obese subjects is not known and is addressed in the present study.

Methods: Cardiovascular events were recorded over a follow-up period of 10 years in a large high-risk population of 1731 consecutive patients undergoing coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). Obesity was defined as BMI ≥30kg/m2.

Results: At baseline, CRP surprisingly was significantly higher in non-obese subjects (n=452) than obese individuals (0.6±1.5 vs. 0.5±0.8 mg/dl; p<0.001). Prospectively, 27.8% of our patients suffered vascular events. CRP proved to be a strong and independent predictor of vascular events in non-obese subjects (HR 1.13 [1.06-1.20]; p<0.001) but not in obese subjects (HR 1.08 [0.94-1.235]; p=0.262). An interaction term BMI x CRP was significant (p<0.001), indicating that the body mass index significantly modulated the power of CRP to predict vascular events.

Conclusions: From the results of this large 10-year prospective cohort study we conclude that obesity significantly modulates the power of CRP to predict cardiovascular event risk among angiographied coronary patients.

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