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Association of small dense LDL serum levels and circulating monocyte subsets in patients with stable coronary artery disease

Session Poster session 3

Speaker Konstantin A Krychtiuk

Event : ESC Congress 2014

  • Topic : coronary artery disease, acute coronary syndromes, acute cardiac care
  • Sub-topic : Coronary Artery Disease – Pathophysiology and Mechanisms
  • Session type : Poster Session

Authors : KA Krychtiuk (Vienna,AT), SP Kastl (Vienna,AT), T Pongratz (Vienna,AT), G Goliasch (Vienna,AT), L Gaspar (Bratislava,SK), J Wojta (Vienna,AT), E Dostal (Vienna,AT), S Pfaffenberger (Vienna,AT), S Oravec (Bratislava,SK), WS Speidl (Vienna,AT)

K.A. Krychtiuk1 , S.P. Kastl1 , T. Pongratz2 , G. Goliasch1 , L. Gaspar3 , J. Wojta1 , E. Dostal2 , S. Pfaffenberger1 , S. Oravec3 , W.S. Speidl1 , 1Medical University of Vienna, Department of Internal Medicine II, Division of Cardiology - Vienna - Austria , 2Krankenanstalten Dr. Dostal - Vienna - Austria , 3University Hospital Bratislava, Department of Internal Medicine II - Bratislava - Slovak Republic ,

European Heart Journal ( 2014 ) 35 ( Abstract Supplement ), 487

Background: Atherosclerosis is considered to be an inflammatory disease in which monocytes and monocyte-derived macrophages play a key role. Circulating monocytes can be divided into three distinct subtypes, namely in classical monocytes (CM; CD14++CD16-), intermediate monocytes (IM; CD14++CD16+) and non-classical monocytes (NCM; CD14+CD16++). Low density lipoprotein particles are heterogeneous in size and density, with small, dense LDL (sdLDL) crucially implicated in atherogenesis. The aim of this study was to examine whether monocyte subsets are associated with LDL subfractions.

Methods: We included 90 patients with angiographically stable coronary artery disease and determined monocyte subtypes by flow cytometry. sdLDL was measured by an electrophoresis method on polyacrylamide gel.

Results: Patients with sdLDL levels in the highest tertile (sdLDL≥4mg/dL;T3) showed the highest levels of pro-inflammatory NCM (15.2±7% vs. 11.4±6% and 10.9±4%, respectively; p<0.01) when compared with patients in the middle (sdLDL=2-3mg/dL;T2) and lowest tertile (sdLDL=0-1mg/dL;T1). Furthermore, patients in the highest sdLDL tertile showed lower CM levels than patients in the middle and lowest tertile (79.2±8% vs. 83.9±7% and 82.7±5%; p<0.01 for T3 vs. T2+T1). Levels of IM were not related to sdLDL levels (5.6±4% vs. 4.6±3% vs. 6.4±3% for T3, T2 and T1, respectively). Furthermore, sdLDL levels were not associated with inflammatory markers. In contrast, total LDL levels were not associated with monocyte subset distribution.

Conclusion: The atherogenic lipoprotein fraction sdLDL is associated with an increase of NCM and a decrease of CM. This could be a new link between innate immunity, lipid metabolism dysregulation and atherosclerosis.

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