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Increased rate of cardiovascular events in patients with high carotid plaque temperature. Insights from a new noninvasive method

Session Optical coherence tomography: finding the cause

Speaker Konstantinos Toutouzas

Event : ESC Congress 2014

  • Topic : basic science
  • Sub-topic : Atherosclerosis, Cerebrovascular Diseases, Aneurysm, Restenosis
  • Session type : Moderated Posters

Authors : G Benetos (Athens,GR), K Toutouzas (Athens,GR), M Drakopoulou (Athens,GR), C Nikolaou (Athens,GR), M Divani (Athens,GR), I Vagena (Athens,GR), A Synetos (Athens,GR), D Tousoulis (Athens,GR), E Siores (Bolton,GB), C Stefanadis (Athens,GR)

G. Benetos1 , K. Toutouzas1 , M. Drakopoulou1 , C. Nikolaou1 , M. Divani1 , I. Vagena1 , A. Synetos1 , D. Tousoulis1 , E. Siores2 , C. Stefanadis1 , 1Hippokration Hospital, University of Athens, 1st Department of Cardiology - Athens - Greece , 2University of Bolton, Centre for Material Research and Innovation - Bolton - United Kingdom ,

European Heart Journal ( 2014 ) 35 ( Abstract Supplement ), 698-699

Purpose: Controversy exists regarding the prognostic role of inflammation in coronary artery disease (CAD). Microwave radiometry (MWR) is a new noninvasive method, which allows the in vivo measurement of the internal temperature of tissues reflecting local inflammation. The aim of the present study was to evaluate in patients with CAD the prognostic value of carotid atherosclerotic plaque inflammation, as assessed by MWR, in cardiovascular events.

Methods: Consecutive patients with significant CAD documented by coronary angiography were evaluated by 1) ultrasound echo-color Doppler (US-ECD) study of both carotid arteries, and 2) microwave radiometry (MWR). During the ultrasound study, carotid plaque thickness was evaluated in all carotids. Temperature difference (ΔT) by MWR was assigned as maximal temperature along the carotid artery minus minimum. ΔT ≥0.90°C was assigned as high ΔT. Major cardiovascular event (MACE) was defined as death, stroke, myocardial infarction or revascularization. All patients were followed-up clinically.

Results: We included 74 consecutive patients with significant CAD. Eight patients (10.8%) had high ΔT temperatures bilaterally. The mean follow-up period for all patients was 12.12±7.9 months. MACE was 37.5% in the group with bilateral high ΔT and 13.6% in non-high ΔT group (p=0.08). By multivariate logistic regression analysis, ΔT was an independent predictor for MACE, when adjusted for sex, age contemporary risk factors, number of vessels with significant stenosis and carotid plaque thickness (OR: 8.55, 95% CI 1.09-67.00, p=0.04). In Kaplan-Meier plots patients with bilateral high ΔT showed higher event rates, compared with patients in non-high ΔT group (log-rank p=0.02).

Conclusions: Evaluation of functional characteristics of carotid plaques through Microwave Radiometry may have incremental prognostic impact on risk assessment of CAD patients.

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