Methods: The study population consisted of 42 pts, (5 ? and 37?), mean age 53±9 years, diagnosed as significant OSAS (Apnea-hypopnea index-AHI =30/h) with frequent ventricular ectopy on 24h Holter monitoring (=60/h) and without significant heart disease. They underwent 24h Holter monitoring before initiation of continuous positive airway pressure (CPAP) and after 6 months time. HRT analysis with calculation of 2 parameters, turbulence onset (TO) and turbulence slope (TS) was performed followed by comparisons between the 2 groups. Abnormal values: TO>0, TS<2.5msec/RR. Ventricular ectopy burden was recorded and was correlated to HRT before and after CPAP.
Results: Only 13 pts of 42, 2? and 11?, (30%) demonstated increased adherence to CPAP. Significant negative correlation between TS and OSAS severity (AHI) (r = 0.51, p < 0.01) was found. TO was higher and TS lower in the non-compliant group. TS was significantly lower in the compliant group before CPAP (1.80 ± 1.05 v 6.05 ± 2.2, p<0.01) and TS improvement was associated with ventricular ectopy elimination.
Conclusion: In OSAS pts, adherent to CPAP, with frequent ventricular ectopy and without underlying heart disease, significant improvement of HRT, mainly TS, was found associated with electrical stability.