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Severe functional mitral valve regurgitation and right ventricular dysfunction as independent predictors of poor response in HF patients after CRT therapy implementation.

Session Poster session 1

Speaker Eftihia Simeonidou

Congress : EHRA 2019

  • Topic : arrhythmias and device therapy
  • Sub-topic : Cardiac Resynchronization Therapy
  • Session type : Poster Session
  • FP Number : P543

Authors : E Simeonidou (Athens,GR), C Pantsios (Athens,GR), G Giannakakis (Athens,GR), V Mpistola (Athens,GR), J Parissis (Athens,GR), G Filippatos (Athens,GR), E Iliodromitis (Athens,GR)

E Simeonidou1 , C Pantsios1 , G Giannakakis1 , V Mpistola1 , J Parissis1 , G Filippatos1 , E Iliodromitis1 , 1Attikon University Hospital, 2nd University Cardiology Dept - Athens - Greece ,


Purpose: Although cardiac resynchronization therapy (CRT) in severe heart failure (HF) patients (pts) was expected to improve functional mitral regurgitation (FMR) by the induction of reverse remodeling, not all pts manifest MR reduction. Additionally, there is evidence of inverse association between right ventricular dysfunction (RVD) and response to CRT. Aim of the study was to evaluate the impact of severe FMR associated with severe right ventricular dysfunction to the outcome of HF status in pts receiving CRTD.

Methods: The study population consisted of 67 severe HF pts with LBBB, on optimal medical treatment, who received CRTD, (10?  and 57?), mean age 61±15 years, 33 with underlying disease ischemic cardiomyopathy and 34 with dilated cardiomyopathy. Most of them underwent optimization of CRT parameters at rest and on exercise. They underwent clinical evaluation and echocardiography assessment of LV dimensions, LVEF, MR quantification, RV dimensions, RVEF and tricuspid annular plane systolic excursion (TAPSE) before CRTD, after 6 months and long-term (6±2 years). Baseline FMR was present in 88% of pts (mild 20, moderate 30, severe 9 pts), severe RVD in 7pts (TAPSE<15mm).

Results: Forty-eight pts were CRT good clinical responders, 8 super responders and 11 pts poor responders. Twenty-three pts with moderate MR and 1 out of 9 pts with severe MR were good responders with early improvement of MR. Six pts (poor responders, severe FMR and severe RVD) died of pump failure. Two pts underwent surgical MR repair and 2 Percutaneous Mitral Clip with mild improvement of MR and HF. Severe baseline FMR and RVD TAPSE<15mm) were associated with hospital readmissions and poor survival (Kaplan-Meier analysis, p<0.001).

Conclusion: Severe baseline FMR and RVD are independent harbingers of resistant HF, unresponsive to CRT implementation and are associated with hospital readmissions and increased mortality and morbidity.

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